(S)-(+)-3-Hydroxytetrahydrofuran

Product Overview

(S)-(+)-3-Hydroxytetrahydrofuran is a specialized chiral organic compound widely recognized for its pivotal role in modern pharmaceutical synthesis. As a key building block, this substance serves as an essential intermediate in the production of advanced kinase inhibitors, most notably Afatinib. Our manufacturing process ensures exceptional stereochemical purity, which is critical for maintaining the efficacy and safety profiles of downstream therapeutic agents. We understand the rigorous demands of the pharmaceutical industry and provide this intermediate with comprehensive documentation and quality assurance.

This compound features a tetrahydrofuran ring structure with a hydroxyl group at the third position, configured in the S-enantiomeric form. The precise chirality is maintained through advanced asymmetric synthesis techniques, ensuring minimal racemization. This level of precision is vital for medicinal chemists developing targeted oncology treatments where biological activity is highly dependent on molecular geometry.

Technical Specifications

Industrial Applications

The primary application of (S)-(+)-3-Hydroxytetrahydrofuran lies within the pharmaceutical sector, specifically in the synthesis of epidermal growth factor receptor (EGFR) inhibitors. It acts as a crucial chiral fragment that imparts specific spatial configuration to the final drug molecule. Beyond Afatinib, this intermediate holds potential for use in various other medicinal chemistry programs requiring chiral tetrahydrofuran motifs.

• Essential intermediate for Afatinib manufacturing
• Used in the development of kinase inhibitors
• Applicable in asymmetric organic synthesis routes
• Serves as a chiral building block for complex APIs

Quality Assurance and Storage

We adhere to strict quality management systems to ensure every batch meets or exceeds industry standards. Each shipment is accompanied by a Certificate of Analysis (COA) detailing purity, identity, and physical constants. Our facility operates under controlled conditions to prevent contamination and ensure product stability. Regarding safety, this material is classified under Hazard Class 8 (Corrosive) with UN Number 3265. Proper handling procedures, including the use of personal protective equipment, are mandatory during transfer and storage.

For optimal preservation, store the product in a cool, ventilated area away from direct sunlight and incompatible materials. We offer flexible packaging options, including 200 kg drums, and can accommodate custom requirements based on logistical needs. As a global manufacturer, we are committed to providing reliable supply chains, competitive bulk pricing, and technical support for your synthesis projects. Contact our sales team for detailed specifications and regulatory documentation.