Intermediates

(S)-(-)-4-Isopropyl-2-oxazolidinone

  • CAS No.17016-83-0
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity chiral auxiliary for asymmetric synthesis. Ideal for pharmaceutical intermediates manufacturing with guaranteed stereochemical integrity.

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Product Technical Details

Product Overview

(S)-(-)-4-Isopropyl-2-oxazolidinone is a premier chiral auxiliary extensively utilized in modern organic synthesis and pharmaceutical manufacturing. As a critical building block, this compound enables chemists to achieve high levels of stereocontrol during complex molecular construction. Our facility produces this material under strict quality management systems to ensure consistent optical purity and chemical integrity for demanding research and production environments.

This oxazolidinone derivative serves as a foundational reagent in the development of enantiomerically pure compounds. By leveraging the steric hindrance provided by the isopropyl group, it facilitates highly selective reactions that are essential for creating active pharmaceutical ingredients (APIs) and advanced fine chemicals. We specialize in supplying bulk quantities to support scale-up from laboratory discovery to industrial production.

Technical Specifications

ParameterSpecification
CAS Number17016-83-0
Molecular FormulaC6H11NO2
Molecular Weight129.16 g/mol
Purity>98%
AppearanceWhite to off-white crystals
Melting Point70-73 °C
Boiling Point291.1 °C at 760 mmHg
Density1.038 g/cm3
Optical Rotation-17.5 ° (C=6, EtOH)
Storage0-6 °C

Industrial Applications

The primary utility of (S)-(-)-4-Isopropyl-2-oxazolidinone lies in its role as a chiral controller in asymmetric synthesis. It is frequently employed in Evans aldol reactions and alkylation processes where precise stereochemical outcomes are mandatory. Pharmaceutical companies rely on this intermediate to construct complex molecular architectures with defined chirality, reducing the need for costly separation processes later in the synthesis pipeline.

Beyond pharmaceuticals, this compound supports the production of agrochemicals and specialty materials requiring specific optical activity. Our manufacturing process ensures low levels of impurities, making it suitable for sensitive catalytic systems. The robustness of the oxazolidinone ring allows it to withstand various reaction conditions while maintaining its chiral information throughout the synthetic sequence.

Quality Assurance and Storage

We understand that consistency is vital for process chemistry. Every batch undergoes rigorous analytical testing, including HPLC and polarimetry, to verify purity and optical rotation values. Customers receive a comprehensive Certificate of Analysis (COA) with each shipment. To maintain stability, the product should be stored in a cool, dry place between 0-6 °C, protected from moisture and direct light. Proper storage ensures the material retains its reactivity and stereochemical properties over extended periods.