(S)-(+)-Glycidyl Phthalimide

Product Overview

(S)-(+)-Glycidyl Phthalimide is a high-value chiral intermediate widely employed in the asymmetric synthesis of active pharmaceutical ingredients (APIs). With its well-defined stereochemistry and reactive epoxide functionality, this compound serves as a critical precursor in the production of anticoagulant therapeutics, most notably Rivaroxaban (CAS: 366789-02-8). Our product is manufactured under stringent quality control protocols to ensure exceptional enantiomeric and chemical purity suitable for regulated pharmaceutical applications.

Specifications

Quality Assurance

Each batch undergoes comprehensive analytical validation to meet or exceed industry standards for pharmaceutical intermediates. Key quality attributes include:

• Assay (HPLC): ≥99.0%
• Optical Purity: ≥99.0% ee
• Moisture Content: ≤0.5%
• Heavy Metals: ≤10 ppm
• Residue on Ignition: ≤0.1%

The material appears as a free-flowing white powder and is packaged in 25 kg drums or customized containers upon request. Storage in a cool, dry, and well-ventilated area is recommended to maintain stability and performance.

Industrial Applications

Primarily utilized as a chiral synthon in advanced organic synthesis, (S)-(+)-Glycidyl Phthalimide enables the efficient construction of complex molecular architectures required in modern drug development. Its primary application lies in the multi-step synthesis of Rivaroxaban, a direct Factor Xa inhibitor used globally for thrombosis prevention. Due to its high enantiomeric integrity and reactivity, it is also explored in the development of other neurological and cardiovascular therapeutics requiring precise stereochemical control.