Sodium 2-Chloro-2,2-Difluoroacetate
- CAS No.1895-39-2
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity Sodium 2-Chloro-2,2-Difluoroacetate is a critical pharmaceutical intermediate used primarily in the synthesis of Roflumilast. We offer bulk quantities with strict quality control and comprehensive documentation.
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Product Overview
Sodium 2-Chloro-2,2-Difluoroacetate represents a vital fluorinated building block within the modern pharmaceutical landscape. As a specialized sodium salt derivative, this compound plays an indispensable role in the construction of complex organic molecules, particularly those requiring precise fluorination patterns to enhance metabolic stability and bioavailability. Our manufacturing facility produces this intermediate under stringent quality management systems to ensure consistency across every batch.
The chemical structure incorporates both chlorine and fluorine atoms on the acetate backbone, providing unique reactivity profiles essential for downstream synthetic transformations. This specific arrangement allows medicinal chemists to introduce difluoro motifs efficiently, which is a common strategy in developing treatments for respiratory conditions and inflammatory diseases.
Key Specifications
| Parameter | Specification |
|---|---|
| CAS Number | 1895-39-2 |
| Molecular Formula | C2ClF2NaO2 |
| Molecular Weight | 152.460 |
| Appearance | White to light yellow powder |
| Assay | ≥98.0% |
| Melting Point | 196-198 °C |
| Density | 1.483 g/cm3 |
Industrial Applications
The primary application of Sodium 2-Chloro-2,2-Difluoroacetate lies in its function as a key intermediate for the synthesis of Roflumilast. Roflumilast is a well-known phosphodiesterase-4 (PDE4) inhibitor used in the management of chronic obstructive pulmonary disease (COPD). The high purity of this precursor is critical, as impurities can affect the efficacy and safety profile of the final active pharmaceutical ingredient (API).
Beyond this specific use, fluorinated acetates are increasingly valuable in agrochemical research and materials science. The presence of fluorine atoms often imparts desirable properties such as increased lipophilicity and resistance to enzymatic degradation. Our team supports clients in optimizing their synthesis routes to maximize yield while minimizing waste.
Quality Assurance and Packaging
We understand that reliability is paramount in the pharmaceutical supply chain. Each production lot undergoes rigorous analytical testing, including HPLC and NMR spectroscopy, to verify identity and purity. A Certificate of Analysis (COA) is provided with every shipment to facilitate your internal quality control processes.
Standard packaging consists of 25 kg drums, designed to protect the material from moisture and contamination during transit. However, we offer flexible packaging solutions tailored to specific customer requirements. Storage recommendations include keeping the product in a cool, ventilated area away from incompatible substances. Partner with us for a secure supply of high-performance chemical intermediates.
