Intermediates

tert-Butyl 3-oxoazetidine-1-carboxylate

  • CAS No.398489-26-4
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

Premium grade tert-Butyl 3-oxoazetidine-1-carboxylate (CAS 398489-26-4) designed for pharmaceutical synthesis. High purity intermediate for Baricitinib production with reliable supply chain.

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Product Technical Details

Product Overview

tert-Butyl 3-oxoazetidine-1-carboxylate is a highly specialized chemical intermediate utilized extensively in the pharmaceutical industry. This compound serves as a critical building block in the synthesis of complex organic molecules, particularly within the realm of advanced therapeutic agents. Our manufacturing process ensures exceptional purity and consistency, meeting the rigorous demands of modern drug development pipelines.

As a protected azetidinone derivative, this material offers superior stability during multi-step synthesis routes. The tert-butoxycarbonyl (Boc) protecting group facilitates selective reactions, making it an indispensable reagent for chemists focused on constructing nitrogen-containing heterocycles. We maintain strict quality control protocols to guarantee that every batch adheres to international standards for pharmaceutical intermediates.

Key Features and Advantages

  • High Chemical Purity: Assay levels consistently exceed 98.0 percent, minimizing impurities in downstream reactions.
  • Stable Structure: The Boc protection ensures robustness during storage and handling under recommended conditions.
  • Versatile Reactivity: Designed for efficient incorporation into complex molecular frameworks such as kinase inhibitors.
  • Reliable Supply: Global manufacturing capabilities ensure timely delivery for large-scale production needs.
  • Comprehensive Documentation: Each shipment includes a Certificate of Analysis (COA) for full traceability.

Technical Specifications

ParameterValue
Chemical Nametert-Butyl 3-oxoazetidine-1-carboxylate
CAS Number398489-26-4
Molecular FormulaC8H13NO3
Molecular Weight171.194 g/mol
AppearanceOff-white crystals
Assay≥98.0%
Melting Point49-52 ºC
Boiling Point251.3±33.0 ºC at 760 mmHg
Density1.2±0.1 g/cm3
Flash Point105.8±25.4 ºC

Industrial Applications

This compound is primarily employed as a key intermediate in the synthesis of pharmaceutical active ingredients. It plays a vital role in the production pathway of specific Janus kinase inhibitors, such as Baricitinib, which are used in the treatment of autoimmune conditions. The precise structural attributes of this azetidinone derivative enable efficient coupling reactions, reducing overall synthesis time and improving yield rates in industrial settings.

Beyond specific API synthesis, it serves as a valuable building block for research and development in medicinal chemistry. Laboratories utilizing this material benefit from its consistent performance in nucleophilic substitution and reduction reactions. Our team supports clients with technical guidance to optimize integration into their specific manufacturing processes.

Storage and Handling

To maintain optimal quality, store this product in a cool, ventilated area away from direct sunlight and moisture. The material should be kept in tightly sealed containers to prevent degradation. Standard industrial safety precautions apply during handling, including the use of appropriate personal protective equipment. We offer flexible packaging options, including 25 kg drums, customized to meet specific logistical requirements for global shipment.