tert-Butyldimethylsilyl Chloride
- CAS No.18162-48-6
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity tert-Butyldimethylsilyl Chloride (TBDMSCl) for advanced organic synthesis. Reliable silylating agent with >=99.0% purity and global supply.
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Product Overview
tert-Butyldimethylsilyl Chloride, commonly abbreviated as TBDMSCl or TBDMS-Cl, is a premier silylating agent utilized extensively in modern organic synthesis and pharmaceutical intermediate manufacturing. This reagent is essential for the protection of hydroxyl groups during complex multi-step synthesis routes. Our facility produces this chemical with rigorous quality control standards to ensure consistent performance in sensitive chemical reactions.
As a leading global manufacturer, we provide this silane coupling agent with exceptional purity levels suitable for research and industrial scale applications. The compound functions by converting alcohols into tert-butyldimethylsilyl ethers, which are stable under various conditions yet can be selectively removed when needed. This versatility makes it a cornerstone reagent in the production of advanced organic compounds.
Key Chemical Properties
The physical and chemical characteristics of tert-Butyldimethylsilyl Chloride are optimized for handling and reactivity. It presents as a white crystalline solid with a distinct melting point range that facilitates easy processing. The high volatility and specific reactivity profile allow for efficient silylation reactions under mild conditions.
- High reactivity towards alcohols, amines, and carboxylic acids
- Stable under neutral and basic conditions
- Compatible with a wide range of organic solvents
- Low moisture sensitivity when stored correctly
Industrial Applications
This silylating agent is primarily employed in the synthesis of pharmaceutical intermediates, agrochemicals, and fine chemicals. It is particularly valuable in protecting group strategies where selective derivatization is required. Common uses include the protection of primary and secondary alcohols during nucleotide synthesis, steroid modification, and carbohydrate chemistry.
Furthermore, it serves as a critical component in the manufacturing of silicone-based materials and surface modification agents. The ability to introduce the TBDMS group enhances the lipophilicity and stability of target molecules, improving their handling properties during downstream processing.
Quality Specifications
We adhere to strict factory standards to guarantee product integrity. Each batch undergoes comprehensive analysis using gas chromatography and other advanced techniques to verify purity and identity. The following table outlines our standard specification parameters:
| Items of Analysis | Standard of Analysis | Test Results |
|---|---|---|
| Appearance | White crystal | White crystal |
| Identification | Retention time corresponds to standard | Conforms |
| Purity (GC) | ≥99.0% | 99.1% |
| t-Butyldimethylsilanol | ≤0.5% | 0.4% |
| Conclusion | Conforms to Factory Standard | |
Storage and Safety
To maintain optimal quality, tert-Butyldimethylsilyl Chloride should be stored in a cool, ventilated place away from moisture and direct sunlight. The packaging consists of 25 kg drums, though custom packaging solutions are available upon request to meet specific logistical requirements. Proper handling procedures should be followed to prevent hydrolysis, which can occur upon exposure to atmospheric humidity.
Our commitment to quality ensures that every shipment includes a Certificate of Analysis (COA). For bulk pricing inquiries or technical support regarding synthesis routes, please contact our sales team directly. We are dedicated to supporting your manufacturing process with reliable chemical solutions.
