trans-4-Aminocyclohexanol
- CAS No.27489-62-9
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity trans-4-Aminocyclohexanol (CAS 27489-62-9), a key pharmaceutical intermediate for ambroxol hydrochloride and other respiratory therapeutics.
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Product Overview
Trans-4-Aminocyclohexanol (CAS 27489-62-9) is a high-value cycloaliphatic amine alcohol widely employed as a critical building block in the synthesis of active pharmaceutical ingredients (APIs). With its well-defined stereochemistry and dual functional groups—primary amine and equatorial hydroxyl—it serves as a versatile scaffold in medicinal chemistry, particularly in the development of mucoactive and bronchodilator agents such as ambroxol hydrochloride.
Specifications
| Molecular Formula | C6H13NO |
|---|---|
| Molecular Weight | 115.17 g/mol |
| Appearance | White to light yellow crystalline powder |
| Assay (GC/HPLC) | ≥99.0% (Typical: 99.28%) |
| Melting Point | 106.0–113.0°C (Observed: 110.0°C) |
| Water Content (KF) | ≤0.50% (Typical: 0.34%) |
| Residue on Ignition | ≤0.20% (Typical: 0.08%) |
| Cis-Isomer Impurity | ≤0.20% (Typical: 0.11%) |
| Density | 1.037 g/cm³ |
| Boiling Point | 127°C at 14 mmHg |
| Flash Point | 75.4°C |
| Refractive Index | 1.502 |
Industrial Applications
As a specialty intermediate in fine chemical manufacturing, trans-4-Aminocyclohexanol is primarily utilized in the multi-step synthesis of respiratory therapeutics. Its rigid cyclohexane ring with trans-configured amine and hydroxyl groups enables precise molecular design for enhanced pharmacokinetic profiles. Beyond ambroxol derivatives, it also finds application in the development of neurological modulators and advanced organic synthesis pathways requiring stereoselective aminocyclohexanol motifs.
- Essential precursor for ambroxol hydrochloride and related mucolytic APIs
- Enables stereospecific construction of bioactive molecules
- Compatible with standard amine and alcohol protection/deprotection strategies
- Supplied with full analytical documentation including COA and spectral data
Storage: Keep in a tightly sealed container under cool, dry conditions, protected from moisture and oxidation to maintain stability and purity.
