Trifluoroacetic Anhydride
- CAS No.407-25-0
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity Trifluoroacetic Anhydride (CAS 407-25-0), a key fluorinated reagent widely used in the synthesis of pharmaceutical intermediates and agrochemicals.
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Product Overview
Trifluoroacetic Anhydride (TFAA), with CAS number 407-25-0, is a highly reactive fluorinated acylating agent extensively employed in advanced organic synthesis. As a colorless, transparent liquid with exceptional electrophilicity, it serves as a critical building block in the production of complex active pharmaceutical ingredients (APIs) and specialty agrochemicals. Its strong electron-withdrawing trifluoromethyl group enhances reactivity in esterification, amidation, and protection/deprotection strategies under mild conditions.
Specifications
| Molecular Formula | C₄F₆O₃ |
|---|---|
| Molecular Weight | 210.03 g/mol |
| Appearance | Colorless transparent liquid |
| Purity | ≥99% |
| Sulphate | ≤0.05% |
| Fluoride | ≤0.005% |
| Chloride | ≤0.005% |
| Density | 1.511 g/mL at 20°C |
| Boiling Point | 39.5–40°C |
| Melting Point | -63.5°C |
| Flash Point | -26°C |
| Refractive Index | n²⁰/D 1.300 |
Industrial Applications
Trifluoroacetic Anhydride is primarily utilized as a high-performance intermediate in the synthesis of several regulated pharmaceutical compounds, including Olanzapine (CAS 132539-06-1) and its pamoate hydrate salt (CAS 221373-18-8), as well as the insecticide Chlorfenapyr (CAS 122453-73-0). Its role in introducing trifluoroacetyl protecting groups or activating carboxylic acids makes it indispensable in multi-step syntheses requiring stringent selectivity and yield optimization. Due to its moisture sensitivity and reactivity, it is handled under anhydrous conditions in controlled environments.
Key advantages of our TFAA include:
- Consistently high purity (≥99%) ensuring reliable reaction outcomes
- Low levels of inorganic impurities (sulphate, chloride, fluoride)
- Optimized for scalability in GMP-compliant manufacturing processes
- Stable under recommended cold-chain storage conditions
Storage & Handling
Store in a sealed container at -20°C in a cool, dry, and well-ventilated area. Keep away from moisture, heat sources, and direct sunlight. Use appropriate personal protective equipment (PPE) due to its corrosive nature and low flash point.
