Intermediates

Trifluoroacetyl chloride

  • CAS No.354-32-5
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

Trifluoroacetyl chloride is a high-purity chemical reagent essential for pharmaceutical intermediate synthesis and organic fluorination processes.

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Product Technical Details

Product Overview

Trifluoroacetyl chloride stands as a critical reagent in modern organic synthesis and pharmaceutical manufacturing. As a highly reactive acid chloride derivative, it serves as a primary source for introducing trifluoroacetyl groups into complex molecular structures. Our facility produces this compound with stringent quality controls to ensure consistency across batches, making it a reliable choice for industrial-scale chemical transformations.

The significance of fluorinated compounds in medicinal chemistry cannot be overstated. Incorporating trifluoroacetyl moieties often enhances the metabolic stability and bioavailability of drug candidates. Consequently, this chemical is indispensable for research laboratories and production plants focused on developing advanced therapeutic agents. We prioritize purity and safety in every cylinder we supply.

Technical Specifications

Our manufacturing process utilizes advanced distillation and purification techniques to achieve superior assay levels. The physical properties listed below reflect the standard specifications for our premium grade product. Each batch undergoes rigorous testing via gas chromatography and spectroscopic analysis to verify compliance with international chemical standards.

ParameterValue
CAS Number354-32-5
Molecular FormulaC2ClF3O
Molecular Weight132.469
AppearanceColorless, irritant gas
Assay≥99.0%
Density1.5±0.1 g/cm3
Boiling Point-19.6±35.0 °C at 760 mmHg
Melting Point−146 °C
Flash Point-58.1±25.9 °C
Vapour Pressure3763.7±0.0 mmHg at 25°C

Industrial Applications

This reagent is predominantly utilized as a key intermediate in the synthesis of pharmaceutical APIs. It plays a crucial role in acylation reactions where high reactivity is required. Notably, it is employed in the production pathways for kinase inhibitors and other targeted therapies. The ability to efficiently transfer the trifluoroacetyl group makes it a preferred choice for process chemists optimizing synthetic routes.

Beyond pharmaceuticals, Trifluoroacetyl chloride finds applications in agrochemical development and materials science. It is used to modify polymer surfaces and create specialized fluorinated compounds with unique thermal and chemical resistance properties. Our clients leverage this versatility to innovate across multiple sectors including biotechnology and fine chemicals.

Quality Assurance and Safety

We understand that handling reactive acid chlorides requires strict adherence to safety protocols. Our product is packaged in certified steel cylinders designed to withstand pressure and prevent leakage. We recommend storage in a cool, ventilated area away from moisture and incompatible substances such as strong bases or oxidizing agents.

Every shipment is accompanied by a comprehensive Certificate of Analysis (COA) detailing the specific batch parameters. Our quality management system ensures traceability from raw material sourcing to final delivery. We are committed to providing not just a chemical product, but a partnership grounded in reliability, safety, and technical support for your synthesis needs.

Packaging and Logistics

Standard packaging consists of 200 Liter steel cylinders, ensuring safe transport of this gaseous reagent. Customized packaging solutions are available upon request to accommodate specific logistical requirements or smaller scale research needs. Our global logistics network facilitates timely delivery to major industrial hubs worldwide, ensuring your production schedules remain uninterrupted.