Trifluoromethanesulfonic Anhydride
- CAS No.358-23-6
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity Trifluoromethanesulfonic Anhydride (CAS 358-23-6) serving as a critical intermediate and catalyst for pharmaceutical and polymer synthesis.
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Product Overview
Trifluoromethanesulfonic Anhydride, commonly known as Triflic Anhydride, is a premier chemical reagent essential for advanced organic synthesis and pharmaceutical manufacturing. As a powerful electrophilic trifluoromethanesulfonylating agent, it facilitates the introduction of the triflate group into various organic molecules. This transformation is critical for enhancing reaction rates and yields in complex synthetic pathways. Our facility produces this compound under strict quality control measures to ensure consistency and reliability for industrial-scale applications.
The compound is characterized by its high reactivity and stability when handled under appropriate conditions. It serves as a cornerstone in the production of nucleosides, antibiotics, steroids, and vitamins. The exceptional leaving group ability of the triflate moiety makes it indispensable for cross-coupling reactions and substitution processes in modern medicinal chemistry.
Technical Specifications
We adhere to rigorous international standards to deliver product quality that meets the demands of research and production environments. The following table outlines the key physical and chemical properties of our Trifluoromethanesulfonic Anhydride.
| Parameter | Value |
|---|---|
| CAS Number | 358-23-6 |
| Molecular Formula | C2F6O5S2 |
| Molecular Weight | 282.14 g/mol |
| Appearance | Colorless clear liquid |
| Assay | ≥99.0% |
| Density | 1.677 g/mL at 25 °C |
| Boiling Point | 81-83 °C |
| Melting Point | -80 °C |
| Refractive Index | n20/D 1.321 |
| Fluorine Content | ≤300 ppm |
| Triflic Acid Content | ≤0.5% |
Industrial Applications
This versatile chemical intermediate finds extensive utility across multiple sectors. In the pharmaceutical industry, it is utilized for the synthesis of active pharmaceutical ingredients (APIs) where high purity is paramount. It acts as a novel and efficient catalyst for Friedel-Crafts benzylation and cyclohexylation reactions, enabling the construction of complex carbon frameworks.
Furthermore, within the plastics and polymer industry, it functions as a polymerization catalyst for oligomerization processes. Its ability to initiate specific chain reactions allows for the precise control of polymer molecular weight and distribution. Researchers also employ this reagent for the preparation of triflates, which are key precursors in palladium-catalyzed coupling reactions such as Suzuki and Stille couplings.
Quality Assurance and Handling
Safety and quality are our top priorities. Each batch undergoes comprehensive testing using advanced analytical techniques including GC and HPLC to verify purity levels. We provide a Certificate of Analysis (COA) with every shipment to ensure transparency and compliance with your internal quality standards.
Due to its corrosive nature and sensitivity to moisture, proper handling procedures are essential. The product should be stored in a cool, dry, and well-ventilated area with containers tightly closed. We offer flexible packaging options, including 37L stainless steel barrels, to accommodate both laboratory-scale research and large-scale manufacturing needs. Our global logistics network ensures timely delivery while maintaining the integrity of the chemical during transit.
