(Trifluoromethyl)trimethylsilane
- CAS No.81290-20-2
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity (Trifluoromethyl)trimethylsilane, a versatile fluorinated intermediate widely used in pharmaceutical R&D and agrochemical synthesis for introducing the trifluoromethyl group.
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Product Overview
(Trifluoromethyl)trimethylsilane, commonly known as the Ruppert-Prakash reagent, is a highly valuable fluorinated organosilicon compound employed as a nucleophilic trifluoromethylating agent in modern organic synthesis. With the molecular formula C4H9F3Si and a molecular weight of 142.20 g/mol, this reagent enables efficient and selective introduction of the -CF3 group into a wide array of electrophilic substrates under mild conditions.
Specifications
| Molecular Formula | C4H9F3Si |
|---|---|
| Molecular Weight | 142.20 g/mol |
| Appearance | Transparent and colorless solution |
| Density | 0.962 g/mL at 20 °C (lit.) |
| Boiling Point | 54–55 °C (lit.) |
| Flash Point | 14 °F |
| Refractive Index | n20/D 1.386 |
| Storage Conditions | 2–8 °C, under inert atmosphere |
Industrial Applications
This compound serves as a critical building block in the development of advanced fluorinated molecules across multiple high-tech sectors:
- In pharmaceutical research, it facilitates the synthesis of trifluoromethylated drug candidates that exhibit enhanced metabolic stability, membrane permeability, and bioavailability.
- In agrochemical innovation, it supports the creation of novel pesticides and herbicides with improved environmental profiles and efficacy.
- In materials science, it contributes to the design of specialty polymers and electronic materials requiring unique thermal, chemical, or dielectric properties imparted by the trifluoromethyl moiety.
As part of a comprehensive fluorochemical platform, our company ensures stringent quality control, consistent batch-to-batch performance, and reliable global supply of this essential intermediate. We support customers with full documentation including Certificates of Analysis (COA), safety data sheets, and technical guidance for scalable synthetic applications.
