Triisopropylsilane
- CAS No.6485-79-6
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity triisopropylsilane (≥99.0% by GC) for use as a reducing agent and deprotection reagent in peptide and fine chemical synthesis.
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Product Overview
Triisopropylsilane (TIPS-H) is a high-purity organosilicon compound widely employed in pharmaceutical and fine chemical manufacturing as a mild and selective reducing agent. With a molecular formula of C9H22Si and a molecular weight of 158.36 g/mol, it serves as a critical reagent in the deprotection of acid-labile protecting groups—particularly in solid-phase peptide synthesis (SPPS)—where it effectively scavenges carbocations without causing side reactions.
Specifications
| Molecular Formula | C9H22Si |
|---|---|
| Molecular Weight | 158.36 g/mol |
| CAS Number | 6485-79-6 |
| Appearance | Clear liquid |
| Purity (GC) | ≥99.0% |
| Density | 0.7726 g/cm³ |
| Boiling Point | 178°C |
| Flash Point | 37.2°C |
| Refractive Index | 1.4358 |
Industrial Applications
Triisopropylsilane is primarily utilized in advanced organic synthesis workflows, especially in the production of complex pharmaceutical intermediates and active pharmaceutical ingredients (APIs). Its key roles include:
- Serving as a non-nucleophilic hydride donor in reductive deprotection steps during peptide chain assembly.
- Acting as an efficient scavenger for reactive cationic species generated during cleavage from resin supports.
- Providing superior selectivity compared to traditional silanes like triethylsilane, minimizing epimerization and side-product formation.
Due to its volatility and flammability (flash point: 37.2°C), it must be handled under inert atmosphere and stored in a cool, well-ventilated area away from ignition sources. Standard packaging is 150 kg per drum, with custom options available upon request to meet GMP and industrial-scale requirements.
