Tris(hydroxymethyl)aminomethane
- CAS No.77-86-1
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity Tris(hydroxymethyl)aminomethane (CAS 77-86-1), widely used as a pharmaceutical intermediate and biochemical buffering agent in drug formulation and laboratory research.
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Product Overview
Tris(hydroxymethyl)aminomethane, commonly known as Trometamol or Tris base, is a versatile organic compound with the molecular formula C4H11NO3 and a molecular weight of 121.14 g/mol. It appears as a white crystalline powder and is highly soluble in water (550 g/L at 25°C). This compound is primarily valued for its excellent buffering capacity in the physiological pH range (pKa ~8.1 at 25°C), making it indispensable in both pharmaceutical manufacturing and life science research.
Specifications
| Appearance | White crystalline powder |
|---|---|
| Assay | ≥99.5% (Typical: 99.96%) |
| Melting Point | 168–172°C (Observed: 170.6–171.8°C) |
| pH (5% aqueous solution) | 10.0–11.5 (Typical: 10.68) |
| Moisture | ≤0.6% (Typical: 0.3%) |
| Heavy Metals | ≤5 ppm |
| Chloride (Cl) | ≤3 ppm |
| Sulfate (SO₄) | ≤10 ppm |
| Iron (Fe) | ≤1 ppm |
| UV Absorbance (40% soln, 280 nm) | ≤0.07 (Typical: 0.067) |
| UV Absorbance (40% soln, 400 nm) | ≤0.02 (Typical: 0.009) |
Industrial Applications
As a key pharmaceutical intermediate, Tris(hydroxymethyl)aminomethane serves multiple critical functions:
- Acts as an acid-base balance regulator in injectable formulations for treating acute metabolic and respiratory acidemia.
- Functions as a primary buffering agent in diagnostic reagents, cell culture media, and electrophoresis buffers.
- Serves as a building block in the synthesis of more complex active pharmaceutical ingredients (APIs) and specialty chemicals.
- Used in cosmetic and nutraceutical formulations where precise pH control is required.
The compound demonstrates high chemical stability when stored properly but is incompatible with strong bases and oxidizing agents. Recommended storage conditions are 2–8°C in a dry, moisture-protected environment to maintain long-term integrity and performance.
