Industrial Manufacturing and Synthesis Route for 5-Fluoro-1-Bromopentane
- High Yield Optimization: Advanced catalytic processes achieve yields exceeding 80% with minimal byproduct formation.
- Industrial Purity Standards: Rigorous rectification ensures mass fraction purity greater than 99.0% for sensitive synthesis.
- Global Supply Chain: Scalable manufacturing capabilities support bulk procurement and custom packaging requirements.
The production of high-performance fluorinated intermediates requires precise control over halogenation mechanisms and purification protocols. 5-Fluoro-1-bromopentane, identified by CAS 407-97-6, serves as a critical chemical building block in the pharmaceutical and agrochemical sectors. As a specialized Alkyl halide, this compound facilitates complex chain extensions and cyclization reactions. At NINGBO INNO PHARMCHEM CO.,LTD., we prioritize technical transparency regarding the manufacturing process to ensure our partners understand the quality parameters inherent in our bulk supply.
This Fluoroalkane derivative is characterized by its specific reactivity profile, allowing for selective substitution reactions. The molecular weight of 169.04 g/mol and boiling point of 130.2 °C necessitate careful thermal management during synthesis. Understanding the underlying synthesis route is essential for procurement teams evaluating technical suitability for large-scale applications.
Industrial Synthesis Pathways
The preparation of Pentane 1-bromo-5-fluoro derivatives typically involves strategic halogen exchange or ring-opening methodologies. While laboratory-scale preparations may utilize exotic fluorinating agents, industrial viability depends on cost-effective raw materials and robust catalysts. Common approaches involve the reaction of fluorinated precursors with brominating agents under controlled acidic conditions.
One efficient pathway utilizes tetrahydropyran derivatives as starting materials. In the presence of Lewis acid catalysts, such as anhydrous zinc chloride or aluminum chloride, the ether linkage is cleaved. Subsequent treatment with hydrogen bromide facilitates the introduction of the bromo functionality while retaining the fluoro substituent. This method avoids the formation of di-halogenated impurities, a common defect in less optimized processes where reaction preference is poor.
Optimization of this synthesis route focuses on minimizing side reactions. For instance, controlling the stoichiometry of acetyl chloride and hydrogen bromide is vital. Excess reagents must be removed via distillation to prevent downstream contamination. The reaction temperature is typically maintained between 0 °C and 120 °C depending on the specific stage, ensuring high conversion rates without degrading the sensitive carbon-fluorine bond.
Reaction Condition Control and Purification
Achieving industrial purity requires stringent monitoring of reaction parameters. Data indicates that maintaining specific molar ratios of catalysts to raw materials significantly impacts the final yield. For example, utilizing a catalyst consumption rate of 1.0% to 20.0% by mass relative to the substrate allows for efficient conversion. Reaction times ranging from 2 to 10 hours are common, followed by phase separation and washing steps.
Purification is typically achieved through vacuum rectification. Collecting the cut at specific pressure and temperature ranges, such as 119 °C to 120 °C under 6 kPa, ensures the isolation of the target Bromofluoropentane isomer. This step is crucial for removing unreacted starting materials and isomeric byproducts. The resulting product typically exhibits a mass fraction purity of 99.0% or higher, meeting the rigorous demands of medicinal chemistry.
When sourcing high-purity 1-Bromo-5-Fluoropentane, buyers should verify the Certificate of Analysis (COA) for residual solvent content and halogen distribution. Proper handling is also required due to the compound’s physical properties, including a specific gravity of 1.571 g/mL and an explosion limit of 1.1% to 14.8% by volume.
Scalability Analysis and Commercial Supply
Transitioning from pilot scale to full production involves addressing heat transfer and mixing efficiency. The exothermic nature of halogenation reactions requires robust cooling systems during the initial addition of reagents. Scalability analysis confirms that the process remains stable when batch sizes are increased, provided that agitation rates are adjusted to maintain homogeneity.
As a global manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. ensures that quality assurance protocols are embedded at every stage of production. This includes raw material inspection, in-process control testing, and final product verification. Bulk pricing structures are designed to support long-term partnerships, with options for factory supply and custom packaging to meet logistical requirements.
The following table outlines the key technical specifications for the commercial grade material:
| Parameter | Specification |
|---|---|
| CAS Number | 407-97-6 |
| Molecular Formula | C5H10BrF |
| Molecular Weight | 169.04 g/mol |
| Purity (GC) | > 99.0% |
| Boiling Point | 130.2 °C |
| Density | 1.571 g/mL |
| Appearance | Colorless Liquid |
Conclusion
The manufacturing of 5-Fluoro-1-bromopentane demands a balance of chemical precision and industrial efficiency. By leveraging optimized catalytic systems and advanced distillation techniques, producers can deliver materials that meet the strictest performance criteria. Whether used for polymer synthesis or pharmaceutical intermediates, the consistency of the supply chain is paramount.
For partners seeking reliable bulk price structures and technical support, NINGBO INNO PHARMCHEM CO.,LTD. stands ready to facilitate your procurement needs. Our commitment to quality assurance and transparent manufacturing processes ensures that your production timelines are met without compromise on chemical integrity.