Industrial Purity and COA Quality Assurance for 1-Bromo-5-Fluoropentane

• Specification: Guaranteed purity ≥99.0% verified by GC analysis.
• Documentation: Comprehensive COA, SDS, and batch-specific traceability.
• Supply: Bulk procurement options with custom packaging for global logistics.

In the realm of fine chemical manufacturing and pharmaceutical intermediates, consistent quality is paramount. 1-Bromo-5-Fluoropentane (CAS: 407-97-6) serves as a critical chemical building block for the introduction of fluorinated alkyl chains into complex molecular structures. As global demand for fluorinated agrochemicals and pharmaceuticals rises, the need for rigorous quality assurance protocols becomes essential. NINGBO INNO PHARMCHEM CO.,LTD. maintains strict manufacturing standards to ensure every batch meets the highest industrial purity specifications required for sensitive downstream reactions.

This technical overview details the purity specifications, Certificate of Analysis (COA) requirements, and impurity control measures necessary for procuring this alkyl halide at scale. Understanding the physicochemical properties and synthesis variability is crucial for process chemists optimizing their synthesis route for maximum yield and minimal waste.

Purity Specifications and Analytical Verification

For industrial applications, a purity threshold of ≥99.0% is the standard benchmark for 1-Bromo-5-Fluoropentane. Achieving this level requires precise fractional distillation and rigorous gas chromatography (GC) monitoring during production. The presence of isomeric impurities or residual starting materials can significantly impact reaction kinetics in subsequent steps, such as nucleophilic substitutions or metal-catalyzed couplings.

Our quality control laboratories utilize high-resolution GC-MS to quantify trace impurities. The typical specification sheet includes limits for water content (Karl Fischer titration), acidity, and related halides. Maintaining low moisture levels is critical, as water can hydrolyze the bromide functionality, leading to the formation of 5-fluoropentan-1-ol, which may interfere with anhydrous reaction conditions. Buyers evaluating bulk price considerations should prioritize suppliers who provide batch-specific data rather than generic typical values, as consistency reduces process validation costs.

Certificate of Analysis (COA) Details

A robust COA is the cornerstone of chemical procurement compliance. For 1-Bromo-5-Fluoropentane, the certificate must reflect actual test results from the specific lot number being shipped, not merely theoretical specifications. Key parameters included in a comprehensive COA are:

• Appearance: Colorless to slightly yellow clear liquid.
• Purity (GC Area %): Minimum 99.0%.
• Density: Verified against standard 1.303 g/cm³ at 25°C.
• Boiling Point: Consistent with 162 °C at 760 mmHg.
• Water Content: Typically ≤0.05% to ensure anhydrous compatibility.

Traceability is maintained through unique lot numbering systems that link the final product back to raw material inputs and process conditions. This level of documentation is essential for regulatory filings in pharmaceutical manufacturing, where change control procedures require full transparency of the supply chain.

Impurity Profile Control

Controlling the impurity profile is as important as establishing the main assay value. In the production of fluorinated alkyl halides, common impurities include dibromo derivatives, unreacted alcohols, or elimination products (alkenes). Advanced manufacturing processes employ specific scavengers and purification steps to minimize these byproducts.

For example, during downstream processing, 1-Bromo-5-Fluoropentane is often utilized in nucleophilic substitutions. Literature data indicates varying yields depending on the reaction conditions. Some protocols report yields around 61% using diethylamino-sulfur trifluoride, while optimized coupling reactions with indole derivatives have demonstrated yields up to 95% under controlled temperatures in DMF. High-purity starting material ensures that these yields are reproducible at scale. When sourcing high-purity 1-Bromo-5-Fluoropentane, buyers should verify that the supplier monitors for halide exchange contaminants which could poison catalysts in nickel or palladium-mediated reactions.

Physical Properties and Handling

Understanding the physical characteristics of the compound is vital for safe storage and handling. The density of 1.303 g/cm³ indicates it is heavier than water, and its flash point of 50.1 °C classifies it as a combustible liquid requiring specific storage conditions. The following table outlines the critical physical properties relevant to logistics and process safety:

Property	Value	Significance
CAS Number	407-97-6	Unique chemical identifier
Molecular Formula	C5H10BrF	Stoichiometric calculations
Molecular Weight	169.037 g/mol	Molar dosing accuracy
Boiling Point	162 °C (760 mmHg)	Distillation parameters
Density	1.303 g/cm³	Volume-to-mass conversion
Flash Point	50.1 °C	Safety and storage class
Refractive Index	1.424	Identity verification

Global Manufacturing and Bulk Procurement

Reliable supply chains are critical for continuous manufacturing operations. NINGBO INNO PHARMCHEM CO.,LTD. operates as a premier global manufacturer, offering scalable production capacities to meet diverse market demands. We provide custom packaging solutions ranging from laboratory-scale bottles to industrial drums and ISO tanks, ensuring product integrity during transit.

Our commitment to quality assurance extends beyond the factory gate. We support our clients with comprehensive technical documentation, including Safety Data Sheets (SDS) and Certificates of Origin (COO), facilitating smooth customs clearance and regulatory compliance. By optimizing our synthesis route for efficiency and environmental safety, we deliver competitive bulk price structures without compromising on the industrial purity required for high-value applications.

For process chemists and procurement specialists seeking a reliable partner for fluorinated intermediates, our facility offers the technical expertise and production capacity necessary to support complex supply chains. Contact our technical sales team to request a sample COA or discuss specific purity requirements for your next campaign.