1-Bromo-5-Fluoropentane Bulk Price Factory Supply
- High purity CAS 407-97-6 available for immediate industrial scaling.
- Competitive bulk pricing tiers with custom packaging options.
- Strict quality assurance with full COA documentation provided.
In the realm of advanced organic synthesis, the demand for specialized fluoroalkylating agents continues to rise, particularly within the pharmaceutical and radiopharmaceutical sectors. 1-Bromo-5-Fluoropentane (CAS: 407-97-6) stands out as a critical chemical building block for constructing complex molecular architectures. As a leading global manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing consistent factory supply chains that meet the rigorous demands of process chemistry and large-scale production.
Procuring this alkyl halide requires more than just checking a catalog; it demands an understanding of purification standards, stability, and logistical scalability. This technical overview details the specifications, manufacturing nuances, and commercial considerations necessary for securing high-quality inventory for your synthesis pipeline.
Technical Specifications and Physical Properties
For process chemists, verifying physical constants is the first step in quality assurance. The material must meet strict density and refractive index criteria to ensure the absence of isomeric impurities or residual solvents. The following table outlines the standard specifications expected for industrial-grade material.
| Property | Specification |
|---|---|
| CAS Number | 407-97-6 |
| Molecular Formula | C5H10BrF |
| Molecular Weight | 169.04 g/mol |
| Appearance | Colorless Liquid |
| Purity (GC) | ≥ 98.0% - 99.0% |
| Boiling Point | 162°C |
| Density | 1.360 g/mL at 25°C |
| Refractive Index | n20/D 1.4406 |
Maintaining industrial purity levels above 98% is essential for downstream reactions, particularly when the intermediate is used in nucleophilic substitutions where side reactions can drastically reduce overall yields. Our quality control protocols ensure that every batch shipped includes a comprehensive Certificate of Analysis (COA) verifying these physical constants against established benchmarks.
Synthesis Route and Manufacturing Process
The production of 5-Fluoro-1-bromopentane typically involves the halogen exchange or direct fluorination of corresponding pentane derivatives. A common synthesis route involves the reaction of 1,5-dibromopentane with a fluoride source, such as potassium fluoride or specialized fluorinating agents, under controlled thermal conditions. The challenge in this manufacturing process lies in selective mono-substitution to prevent the formation of difluoro byproducts or elimination products.
At NINGBO INNO PHARMCHEM CO.,LTD., we utilize optimized catalytic systems to enhance reaction selectivity. Post-reaction purification involves rigorous fractional distillation to isolate the target Bromofluoropentane from unreacted starting materials and higher boiling impurities. This attention to detail ensures that the bulk price reflects not just the volume, but the reduced cost of goods sold (COGS) for our clients due to higher reaction yields in their own processes.
When sourcing high-purity 1-Bromo-5-Fluoropentane, buyers should prioritize suppliers who can demonstrate control over these distillation parameters. Impurities such as free bromine or acidic residues can degrade sensitive catalysts in subsequent steps, making vendor qualification critical.
Commercial Applications and Utility
This fluoroalkane serves as a versatile intermediate in medicinal chemistry. Notably, it has been utilized to prepare 18F-labeled (anilido)piperidine derivatives, which act as μ-opioid receptor imaging agents. The presence of the bromine atom allows for further functionalization, while the fluoro group provides metabolic stability and altered lipophilicity profiles essential for bioavailability.
Beyond radiopharmaceuticals, this alkyl halide is employed in the synthesis of liquid crystals, agrochemicals, and specialized polymers. The dual functionality allows chemists to introduce a fluorine motif at a specific chain length, enabling the fine-tuning of physicochemical properties in the final active pharmaceutical ingredient (API).
Bulk Pricing and Procurement Strategy
Pricing for fine chemicals like this fluctuates based on raw material availability, specifically the cost of fluorinating agents and energy inputs for distillation. Small-scale packaging (25g to 1kg) often carries a significant premium per gram due to packaging and handling costs. However, transitioning to drum-level procurement unlocks significant economies of scale.
Our factory supply model allows for direct negotiation on large volumes. We offer flexible packaging solutions, including glass bottles for laboratory scale and metal drums or IBCs for pilot and production scales. Custom packaging is available to meet specific safety regulations for international transport of halogenated compounds.
Key Procurement Considerations
- Volume Discounts: Significant price reductions apply for orders exceeding 100kg.
- Lead Time: Standard inventory is available for immediate dispatch, with custom synthesis batches requiring 2-4 weeks.
- Documentation: Full regulatory support including MSDS, COA, and stability data is provided with every shipment.
Safety, Handling, and Storage
As with all halogenated organic compounds, proper handling procedures are mandatory. The material is classified as an irritant (H315, H319, H335), causing skin and serious eye irritation, and may cause respiratory irritation. Personnel must wear appropriate personal protective equipment (PPE), including chemical-resistant gloves and safety goggles, during handling.
Storage should be maintained in a cool, dry place in tightly closed containers. It is critical to store the material away from oxidizing agents to prevent hazardous reactions. Adequate ventilation is required in storage areas to prevent the accumulation of vapors. For long-term stability, keeping the container under an inert atmosphere such as nitrogen is recommended to prevent hydrolysis or oxidation over time.
Conclusion
Securing a reliable source of Pentane 1-bromo-5-fluoro is vital for maintaining continuity in complex synthesis projects. By partnering with NINGBO INNO PHARMCHEM CO.,LTD., organizations gain access to a supply chain built on technical expertise, quality assurance, and commercial flexibility. Whether for radiolabeling studies or large-scale API production, our commitment to high standards ensures your processes run efficiently and cost-effectively.
Contact our technical sales team today to discuss your specific volume requirements and receive a customized quote for factory supply tailored to your project timeline.