Technical Specification Guide for CAS 50405-39-5: 1-Bromo-1-Butyne
- [Chemical Reactivity]: Optimized halogenation protocols ensure minimal allene formation and high yield for downstream coupling.
- [Logistics Stability]: Secure packaging for volatile alkynyl halides guarantees intact delivery for tonnage quantities.
- [Regulatory Alignment]: Full documentation support including batch-specific COA and SDS for global audit readiness.
In the landscape of fine chemical intermediates, securing a reliable source for volatile halogenated alkynes is critical for maintaining production schedules. CAS 50405-39-5 represents a versatile alkynyl bromide used extensively in cross-coupling reactions and heterocycle synthesis. For process development teams, the distinction between laboratory-grade samples and commercial-scale material often lies in the consistency of the synthesis route and the control of specific impurities. As a premier global manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. prioritizes batch-to-batch consistency to support seamless scale-up from gram to kilogram levels.
Verifying CAS 50405-39-5 Identity vs Isomers
Structural verification is the first step in qualifying any raw material. The molecular formula C4H5Br corresponds to a specific linear arrangement, yet isomeric impurities can arise during production. Common contaminants include positional isomers or over-halogenated byproducts which can poison catalysts in subsequent palladium-coupled steps. Rigorous QC protocols utilize GC-MS and NMR to distinguish the target 1-bromo-but-1-yne structure from potential 2-bromo isomers or dibromo derivatives.
When evaluating potential vendors, R&D departments should request chromatograms that demonstrate the separation of the main peak from closely eluting impurities. The stability of the triple bond adjacent to the halogen requires careful handling during distillation. Our manufacturing process utilizes controlled temperature gradients to prevent thermal decomposition, ensuring the material retains its integrity as a robust organic synthesis building block. For detailed specifications on isomer limits and purity profiles, buyers can review the technical data sheet for 1-Bromo-1-butyne to ensure it meets specific project requirements.
Physical Constants and Assay Requirements
Procurement teams must validate that the physical properties align with the expected behavior of the compound during storage and reaction setup. Variations in boiling point or density often indicate solvent retention or degradation. The table below outlines the critical quality parameters expected for industrial purity grades suitable for pharmaceutical intermediate production.
| Parameter | Specification Standard | Typical Result |
|---|---|---|
| CAS Registry Number | 50405-39-5 | Confirmed |
| Molecular Formula | C4H5Br | Verified |
| Molecular Weight | 132.99 g/mol | 132.99 |
| Assay (GC Area %) | ≥ 98.0% | 98.5% - 99.2% |
| Appearance | Colorless to Pale Yellow Liquid | Clear Liquid |
| Water Content (Karl Fischer) | ≤ 0.5% | < 0.3% |
Maintaining low water content is essential, as moisture can lead to hydrolysis of the bromide, generating acidic byproducts that compromise storage stability. Each batch shipped from our facility undergoes verification against these standards. The accompanying COA provides traceability for every drum, allowing quality assurance teams to cross-reference incoming goods against established benchmarks without delay.
Supplier Audit Requirements for Pharma Intermediates
For executive stakeholders, the viability of a supply chain depends on regulatory compliance and production scalability. Sourcing volatile intermediates requires a partner with established safety protocols and export capabilities. NINGBO INNO PHARMCHEM CO.,LTD. operates under strict quality management systems to ensure that all shipments meet international shipping regulations for hazardous materials.
Commercial viability also hinges on cost efficiency at scale. While spot prices fluctuate, securing a long-term agreement with a direct manufacturer stabilizes the bulk price and protects against market volatility. We recommend conducting a vendor audit that reviews capacity planning, emergency response procedures, and environmental compliance. By partnering with a dedicated chemical producer, organizations mitigate the risk of supply discontinuation and ensure a steady flow of materials for continuous manufacturing processes.
To initiate the qualification process or discuss custom packaging requirements, please contact our technical sales team for a batch-specific COA, SDS, or bulk pricing quote.