Intermediates

1-Bromo-1-butyne

  • CAS No.50405-39-5
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 1-Bromo-1-butyne (CAS 50405-39-5) designed for advanced organic synthesis. Reliable supply for pharmaceutical intermediate manufacturing with strict quality control.

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Product Technical Details

Product Overview

1-Bromo-1-butyne represents a critical alkyne halide building block extensively utilized in modern organic synthesis and pharmaceutical development. As a specialized intermediate, this compound facilitates the construction of complex molecular architectures required for advanced therapeutic agents. Our manufacturing process ensures high consistency and reliability for research and industrial scale applications. The chemical structure features a terminal alkyne group substituted with a bromine atom, providing unique reactivity patterns that are highly sought after in medicinal chemistry.

Derived from precise synthetic routes, this chemical serves as a versatile reagent for coupling reactions and functional group transformations. The structural integrity of the bromo-alkyne moiety allows for diverse chemical modifications, making it indispensable for medicinal chemistry teams focused on novel drug discovery pipelines. We maintain rigorous production standards to minimize impurities and ensure batch-to-batch reproducibility for all clients.

Technical Specifications

Parameter Value
CAS Number 50405-39-5
Molecular Formula C4H5Br
Molecular Weight 132.99 g/mol
Appearance Light yellow liquid
Purity (Assay) 97% min
Density 1.461 g/cm3
Refractive Index 1.49
Flash Point 21.68 C

Industrial Applications

The primary application of 1-Bromo-1-butyne lies within the pharmaceutical intermediate sector. It is frequently employed in the synthesis of active pharmaceutical ingredients (APIs) where alkyne functionality is required. The compound supports various cross-coupling reactions, including Sonogashira coupling, enabling the efficient formation of carbon-carbon bonds. This capability is crucial for extending carbon chains and introducing specific functional groups into target molecules.

  • Pharmaceutical intermediate synthesis
  • Organic synthesis building block
  • Research and development reagent
  • Custom chemical manufacturing feedstock

Chemists value this material for its reactivity profile and stability under controlled conditions. It serves as a key precursor in the development of neurological therapeutics and other complex organic molecules where precision synthesis is paramount. Additionally, it finds utility in academic research settings where novel reaction pathways are explored. The versatility of this intermediate allows it to be integrated into multi-step synthesis routes with high efficiency.

Quality Assurance and Safety

We adhere to strict quality control protocols to ensure every batch meets the specified assay requirements. Each shipment is accompanied by a Certificate of Analysis (COA) verifying purity and physical constants. Our facility maintains compliance with international safety standards for hazardous chemical handling. Regular testing includes verification of density, refractive index, and flash point to guarantee conformity with the provided specifications.

Due to the flash point and chemical nature, proper storage is essential. The product must be kept in sealed containers within a cool, dry warehouse environment away from incompatible substances. We recommend following standard laboratory safety procedures when handling this material to ensure personnel protection. Safety data sheets (SDS) are available upon request to guide safe handling practices.

Packaging and Logistics

To maintain product integrity during transit, 1-Bromo-1-butyne is packaged in secure iron drums with a net weight of 25kg per unit. This packaging solution protects the contents from moisture and physical damage. Our global logistics network ensures timely delivery to laboratories and manufacturing plants worldwide. We utilize robust labeling systems to ensure clear identification and hazard communication during transport.

For bulk orders, customized packaging solutions may be available upon request. We prioritize safe shipping practices compliant with international transportation regulations for chemical goods. Contact our sales team for detailed shipping information and lead times. Our commitment to customer service extends beyond the sale, providing ongoing support for your supply chain needs.