1-Bromo-1-Butyne Bulk Price Global Manufacturer Analysis
- Market Dynamics: Lab-scale pricing often exceeds $90 for 5g, whereas industrial bulk procurement offers significant cost reductions per kilogram.
- Technical Specs: Critical parameters include 98% minimum purity, density of 1.46g/ml, and strict control over halide content for coupling reactions.
- Supply Chain: Secure sourcing requires verified COAs, TSCA compliance checks, and specialized hazardous material logistics.
In the realm of advanced organic synthesis, 1-Bromo-1-butyne (CAS: 50405-39-5) serves as a pivotal alkynyl bromide building block. This halogenated alkyne is frequently utilized in cross-coupling reactions, such as Sonogashira couplings, to construct complex carbon frameworks essential for pharmaceutical intermediates and agrochemicals. For procurement officers and process chemists, understanding the disparity between laboratory reagent costs and industrial manufacturing rates is crucial for budget forecasting. As a premier global manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. specializes in scaling these reactions to meet high-volume demand while maintaining rigorous quality standards.
The molecular formula C4H5Br indicates a relatively low molecular weight of 132.99 g/mol, which impacts shipping calculations and stoichiometric planning. While small-scale research quantities may command premium pricing due to packaging and handling overheads, bulk production leverages economies of scale. The following analysis breaks down the cost structures, logistical considerations, and technical specifications required for successful bulk acquisition.
Volume-Based Pricing Tiers for Intermediates
Pricing for fine chemicals like 1-Brom-but-1-in varies drastically based on order volume. Market data indicates that small packaging (e.g., 5g bottles) can cost upwards of $90, reflecting the high handling costs associated with hazardous alkynyl halides. However, this metric is misleading for industrial planning. When negotiating a bulk price, buyers should expect a exponential decrease in cost per kilogram as volumes move from grams to multi-kilogram or drum quantities.
Manufacturers typically structure pricing into three tiers:
- Sample Tier (10g - 100g): Used for method development and initial screening. Pricing remains high to cover QC and specialized packaging.
- Pilot Tier (1kg - 25kg): Used for process optimization. Prices begin to normalize, reflecting partial production runs.
- Commercial Tier (100kg+): Full-scale production. This tier offers the most competitive rates, optimized for continuous synthesis route integration.
It is vital to distinguish between reagent-grade material and custom-manufactured lots. Reagent suppliers often stock limited quantities at high margins. In contrast, contracting directly with a production facility allows for customization of the industrial purity specifications. For instance, while 98% is standard, specific projects may require tighter controls on isomeric impurities or water content, which can be negotiated at the commercial tier without the prohibitive costs associated with small-batch custom synthesis.
Global Shipping Cost Analysis for Hazardous Chemicals
Shipping 1-Butyne 1-bromo derivatives involves complex logistical planning due to their classification as hazardous materials. The density of approximately 1.46g/ml and a predicted boiling point of 104.3±23.0 °C necessitate specific storage conditions during transit. Unlike non-hazardous solids, liquid alkynyl bromides require UN-certified packaging to prevent leakage and degradation.
Furthermore, regulatory compliance plays a significant role in landed costs. For shipments destined for the United States, verification against the TSCA inventory is mandatory. Current data suggests this specific CAS may not appear on standard TSCA lists, requiring pre-import notifications or exemptions. A reliable supply chain partner manages these regulatory hurdles to prevent customs delays.
When evaluating total landed cost, buyers must account for:
| Logistics Factor | Impact on Cost | Technical Requirement |
|---|---|---|
| Packaging | High | UN-approved drums or fluorinated bottles to prevent halide interaction. |
| Freight Class | Medium | Hazardous goods surcharges apply for air and sea freight. |
| Insurance | Low | Cargo insurance is critical for high-value chemical intermediates. |
| Customs | Variable | HS Code classification and regulatory documentation (COA, MSDS). |
Efficient logistics ensure that the refractive index and purity remain stable upon arrival. Exposure to excessive heat or light during shipping can degrade the product, leading to failed reactions downstream. Therefore, selecting a manufacturer with experience in hazardous material export is as critical as the price per kilogram.
Requesting Wholesale Quotes and Lead Times
Securing a competitive quote requires providing detailed technical requirements to the supplier. Vague inquiries often result in generic pricing that does not reflect the true cost of goods. To obtain an accurate quote for 1-Bromo-1-butyne, procurement teams should specify the required purity level, packaging type, and destination port.
Lead times are another critical variable. Standard stock items may ship within weeks, but custom production runs for large volumes typically require 4 to 8 weeks. This timeline accounts for raw material sourcing, reaction completion, distillation, and quality control testing. NINGBO INNO PHARMCHEM CO.,LTD. maintains robust production schedules to minimize these lead times, ensuring continuity for client manufacturing pipelines.
Essential documentation to request during the quoting phase includes:
- Certificate of Analysis (COA): Verifying purity (GC/HPLC), density, and refractive index.
- Material Safety Data Sheet (MSDS): Updated according to GHS standards for safe handling.
- Stability Data: Information on shelf life and recommended storage conditions.
In conclusion, optimizing the procurement of this alkynyl bromide involves looking beyond the unit price. It requires a holistic view of synthesis compatibility, regulatory compliance, and logistical security. By partnering with an established entity capable of delivering consistent industrial purity and reliable volume, pharmaceutical and chemical companies can secure their supply chains against market volatility.