Fmoc-Thr(tBu)-OL

Product Overview

Fmoc-Thr(tBu)-OL, chemically known as 9H-fluoren-9-ylmethyl N-[(2R,3R)-1-hydroxy-3-[(2-methylpropan-2-yl)oxy]butan-2-yl]carbamate, serves as a critical building block in modern organic synthesis and peptide chemistry. This specialized intermediate features a fluorenylmethyloxycarbonyl (Fmoc) protecting group on the amine and a tert-butyl ether protection on the side chain hydroxyl group. Such dual protection strategy ensures high stability during solid-phase peptide synthesis (SPPS) while allowing for selective deprotection under standard conditions.

Our manufacturing process adheres to strict quality control protocols, ensuring that each batch meets rigorous pharmaceutical standards. The compound is designed for researchers and industrial manufacturers who require reliable materials for the construction of complex peptide sequences and modified amino acid derivatives. With a molecular formula of C23H29NO4 and a molecular weight of 383.48, this substance offers excellent solubility profiles in common organic solvents used in peptide coupling reactions.

Key Specifications

Quality assurance is paramount in the supply of fine chemical intermediates. We provide comprehensive testing data for every production lot to guarantee consistency and performance in downstream applications. The following table outlines the typical analytical standards maintained for this product:

Industrial Applications

This protected amino alcohol is primarily utilized in the pharmaceutical and biotechnology sectors. Its primary function lies in the synthesis of peptide hormones, therapeutic proteins, and diagnostic agents. The Fmoc group is base-labile, making it compatible with acid-labile side-chain protecting groups like the tert-butyl ether present in this molecule. This orthogonality is crucial for multi-step synthesis routes where specific functional groups must be revealed without affecting others.

• Solid-Phase Peptide Synthesis (SPPS) reagent.
• Intermediate for developing novel peptide-based drugs.
• Building block for peptidomimetics and modified proteins.
• Research tool for studying protein structure and function.
• Component in the manufacturing of diagnostic kits.

Storage and Handling

To maintain the integrity of Fmoc-Thr(tBu)-OL, proper storage conditions are essential. The material should be kept in a cool, dry environment, ideally at 0°C, to prevent degradation or hydrolysis of the carbamate linkage. Containers must remain tightly sealed to avoid exposure to moisture and atmospheric contaminants. When handling, standard laboratory safety practices should be followed, including the use of appropriate personal protective equipment. We offer flexible packaging options, including 25 kg drums, to suit both laboratory-scale research and large-scale industrial production needs. Our global logistics network ensures timely delivery while maintaining the cold chain required for sensitive chemical intermediates.