Fmoc-Lys(ivDde)-OH: The Cornerstone of Advanced Peptide Synthesis
Unlock precision in peptide design with our advanced, orthogonally protected lysine building block.
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Fmoc-Lys(ivDde)-OH
Fmoc-Lys(ivDde)-OH is a critical protected amino acid derivative essential for sophisticated peptide synthesis, particularly within the Fmoc (fluorenylmethyloxycarbonyl) solid-phase peptide synthesis (SPPS) strategy. It is designed to incorporate lysine into peptide sequences while providing a selectively cleavable protecting group on its epsilon-amino side chain.
- Achieve precise peptide modifications by leveraging the orthogonal protection offered by the ivDde group on lysine side chains, a key aspect of advanced peptide synthesis.
- Utilize this essential building block for Fmoc-based SPPS, ensuring efficient and reliable incorporation of lysine into your peptide sequences.
- Explore enhanced bioconjugation capabilities through the selective deprotection of the lysine side chain, a vital step in creating labeled or functionalized peptides.
- Facilitate the synthesis of complex peptide architectures, including branched peptides, where the lysine epsilon-amino group serves as a crucial branching point in custom peptide synthesis.
Advantages Provided by the Product
Selective Deprotection
The ivDde group provides selective deprotection capabilities under mild conditions using hydrazine or hydroxylamine, allowing for targeted modifications without affecting other protecting groups in your peptide synthesis.
Orthogonal Protection Strategy
Benefit from an orthogonal protection scheme that makes Fmoc-Lys(ivDde)-OH highly compatible with various Fmoc and other protecting groups, offering flexibility in complex peptide chemistry.
Enhanced Bioconjugation
Easily perform site-specific bioconjugation by selectively deprotecting the lysine side chain, a crucial feature for creating peptide conjugates for research and therapeutic applications.
Key Applications
Peptide Synthesis
As a core building block, Fmoc-Lys(ivDde)-OH is fundamental for Fmoc-based solid-phase peptide synthesis, enabling the precise incorporation of lysine into target peptide sequences.
Bioconjugation
Its selectively cleavable ivDde group makes it ideal for site-specific bioconjugation, allowing the attachment of labels, drugs, or PEG chains to lysine residues in your custom peptide synthesis projects.
Branched Peptides
This derivative is instrumental in the synthesis of branched or multivalent peptides, where the lysine side chain acts as a point for extending the peptide chain.
Therapeutic Peptide Development
Fmoc-Lys(ivDde)-OH plays a vital role in developing therapeutic peptides, ensuring correct lysine incorporation and enabling downstream modifications crucial for drug efficacy and delivery.