In the realm of emulsifiers and surfactants, Span 80 and Tween 80 are two commonly discussed compounds, often used in conjunction to achieve optimal formulation stability and texture. Both are derived from sorbitan but possess distinct chemical structures and properties that dictate their primary applications. Understanding these differences is crucial for formulators in industries ranging from food and cosmetics to pharmaceuticals. NINGBO INNO PHARMCHEM CO.,LTD., a prominent chemical manufacturer and supplier in China, offers both high-quality Span 80 and Tween 80, and we aim to clarify their distinctions to aid your product development.

Understanding the Basics: Span 80 and Tween 80

Sorbitan Monooleate (Span 80), with CAS number 1338-43-8, is a lipophilic, nonionic surfactant. It's a sorbitan ester formed by esterifying sorbitan with oleic acid. Its physical form is typically a light yellow, viscous oily liquid. Span 80 has a low Hydrophilic-Lipophilic Balance (HLB) value, usually around 4.3. This low HLB makes it highly effective at stabilizing water-in-oil (W/O) emulsions, where water droplets are dispersed within an oil phase.

Polysorbate 80 (Tween 80), also known as Polyoxyethylene sorbitan monooleate, is a hydrophilic, nonionic surfactant. It is produced by ethoxylating sorbitan monooleate. Tween 80 is typically a yellow, viscous liquid. It boasts a high HLB value, generally around 15. This high HLB makes it an excellent emulsifier for oil-in-water (O/W) emulsions, where oil droplets are dispersed in a water phase.

Key Differences and Applications

  • Chemical Structure and Hydrophilicity/Lipophilicity: The primary difference lies in the presence of polyoxyethylene chains in Tween 80, which makes it hydrophilic and water-soluble. Span 80 lacks these chains, making it more lipophilic and soluble in oils and organic solvents.
  • HLB Value and Emulsion Type: Span 80's low HLB (4.3) is ideal for W/O emulsions. Tween 80's high HLB (15) is perfect for O/W emulsions.
  • Applications:
    • Span 80 is preferred for: Stabilizing water-in-oil emulsions in creams, ointments, and lotions; acting as a wetting agent and dispersant for lipophilic ingredients in pharmaceuticals and cosmetics; use in certain food products like margarine and shortening; and industrial applications like textile lubricants and paints.
    • Tween 80 is preferred for: Stabilizing oil-in-water emulsions in food products like salad dressings, sauces, and ice cream; creating stable emulsions in cosmetic lotions, shampoos, and skincare products; acting as a solubilizer and stabilizer in pharmaceutical liquid dosage forms and injections; and in various industrial processes requiring O/W emulsification.
  • Synergistic Use: Often, formulators use a combination of Span and Tween surfactants to create complex emulsions with tailored HLB values, offering enhanced stability and versatility. For instance, blending Span 80 with Tween 80 can achieve a balance for specific emulsification needs.

Your Trusted Partner for Emulsifier Sourcing

NINGBO INNO PHARMCHEM CO.,LTD. understands that selecting the right emulsifier is critical for product success. As a leading chemical manufacturer and supplier in China, we offer a comprehensive range of sorbitan esters and polysorbates. Whether you need the W/O stabilizing power of Span 80 or the O/W emulsifying capabilities of Tween 80, we provide high-quality products with reliable supply and competitive pricing. For procurement managers and R&D scientists looking to buy these essential ingredients, we are your dependable partner.

Contact Us for Your Formulation Needs

To ensure you select the most appropriate emulsifier for your product, we encourage you to reach out to our expert team. We can provide technical guidance, product samples, and competitive quotes for your Span 80 and Tween 80 requirements. Partner with NINGBO INNO PHARMCHEM CO.,LTD. for all your specialty chemical needs.