1-Boc-4-(4-Iodo-1H-pyrazol-1-yl)piperidine
- CAS No.877399-73-0
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High purity pharmaceutical intermediate used primarily in the synthesis of kinase inhibitors such as Crizotinib. Available in bulk quantities with full documentation.
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Product Overview
1-Boc-4-(4-Iodo-1H-pyrazol-1-yl)piperidine is a specialized organic compound designed for advanced pharmaceutical synthesis. This molecule features a piperidine ring protected by a tert-butoxycarbonyl (Boc) group, coupled with an iodinated pyrazole moiety. Such structural configuration makes it an invaluable building block in the construction of complex heterocyclic systems found in modern medicinal chemistry. Our facility produces this intermediate under strict quality control standards to ensure consistency and reliability for downstream chemical processes.
The presence of the iodine atom on the pyrazole ring provides a reactive handle for various cross-coupling reactions, including Suzuki and Heck couplings, which are essential steps in assembling active pharmaceutical ingredients (APIs). The Boc protection group ensures stability during synthesis while allowing for facile deprotection when required. This balance of reactivity and stability is critical for efficient manufacturing workflows in the pharmaceutical industry.
Technical Specifications
| Parameter | Value |
|---|---|
| CAS Number | 877399-73-0 |
| Molecular Formula | C13H20IN3O2 |
| Molecular Weight | 377.221 g/mol |
| Appearance | Off-white powder |
| Assay (Purity) | ≥98.0% |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 417.5±55.0 °C at 760 mmHg |
| Flash Point | 206.3±31.5 °C |
Industrial Applications
This compound serves primarily as a key intermediate in the production of kinase inhibitors, notably Crizotinib. Kinase inhibitors are a vital class of therapeutics used in oncology to target specific signaling pathways involved in tumor growth. The high purity of our material ensures minimal impurity carryover into the final drug substance, facilitating regulatory compliance and reducing purification burdens during later synthesis stages.
- Pharmaceutical API Synthesis: Essential building block for anticancer agents.
- Organic Research: Used in method development for heterocyclic chemistry.
- Quality Control: Serves as a reference standard for analytical verification.
- Custom Synthesis: Available for tailored process development projects.
Quality Assurance and Storage
We adhere to rigorous manufacturing protocols to maintain the integrity of this chemical. Each batch is accompanied by a Certificate of Analysis (COA) detailing comprehensive testing results including HPLC purity, NMR structure confirmation, and residual solvent analysis. Proper storage is essential to maintain product stability. We recommend storing the material in a cool, ventilated area away from direct sunlight and moisture. Containers should remain tightly sealed when not in use to prevent degradation or contamination. Packaging options include 25 kg drums or customized solutions based on client logistical requirements. Our global supply chain ensures timely delivery while maintaining cold chain or standard shipping conditions as appropriate for the material stability profile.
