2,3,4-Trifluorobromobenzene

Product Overview

2,3,4-Trifluorobromobenzene represents a critical class of fluorinated aromatic compounds utilized extensively in modern organic synthesis. As a specialized halogenated benzene derivative, this chemical serves as a fundamental building block for the development of complex molecular structures. Our manufacturing facility adheres to strict quality control protocols to ensure consistent purity and reliability for downstream processing.

The unique substitution pattern of fluorine atoms at the 2, 3, and 4 positions combined with a bromine moiety provides distinct reactivity profiles. This makes the compound particularly valuable for cross-coupling reactions and nucleophilic aromatic substitutions. We supply this material to support research and industrial scale production requiring precise chemical specifications.

Key Specifications

Physical and Chemical Properties

This fluorinated intermediate exhibits stable physical characteristics suitable for various reaction conditions. The density is recorded at 1.777 g/mL at 25 degrees Celsius, indicating a heavy liquid phase typical of polyhalogenated aromatics. The boiling point ranges around 152.6 degrees Celsius at 760 mmHg, allowing for distillation purification if required under controlled environments.

With a flash point of 144 degrees Fahrenheit, standard industrial safety precautions should be observed during handling and storage. The refractive index is measured at 1.487, which serves as a key quality control identifier for batch consistency. Our analytical team verifies these parameters against certified reference standards to guarantee performance in your synthesis workflows.

Industrial Applications

Primarily utilized as a pharmaceutical intermediate, this compound facilitates the introduction of fluorine atoms into drug candidates. Fluorination is a strategic modification in medicinal chemistry to enhance metabolic stability and bioavailability. The bromine handle allows for palladium-catalyzed coupling reactions, enabling the construction of biaryl systems common in active pharmaceutical ingredients.

Beyond pharmaceuticals, this reagent finds application in agrochemical synthesis and materials science. Researchers leverage the electron-withdrawing nature of the trifluoro substitution to modulate the electronic properties of target molecules. Whether for custom synthesis or large-scale manufacturing, our product provides a reliable foundation for innovation in fine chemicals.

Storage and Handling

To maintain optimal quality, store this material in a tightly closed container within a cool, dry, and well-ventilated area. The recommended storage temperature is between 2 to 8 degrees Celsius. Keep away from incompatible substances such as strong oxidizing agents or bases that may induce unwanted side reactions. Always consult the safety data sheet for comprehensive handling instructions and personal protective equipment requirements.