2-Chloro-3-fluoro-4-iodopyridine
- CAS No.148639-07-0
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 2-Chloro-3-fluoro-4-iodopyridine (≥98.0%) for use as a key building block in advanced pharmaceutical synthesis.
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Product Overview
2-Chloro-3-fluoro-4-iodopyridine is a highly functionalized halogenated pyridine derivative widely employed as a critical intermediate in modern medicinal chemistry and pharmaceutical development. Its unique combination of chlorine, fluorine, and iodine substituents at specific positions enables selective cross-coupling reactions, making it invaluable for constructing complex drug scaffolds under controlled synthetic conditions.
Specifications
| CAS Number | 148639-07-0 |
|---|---|
| Molecular Formula | C5H2ClFIN |
| Molecular Weight | 257.43 g/mol |
| Appearance | Yellow liquid |
| Purity | ≥98.0% (by GC or HPLC) |
| Density | 2.1 ± 0.1 g/cm³ |
| Boiling Point | 246.1 ± 35.0 °C at 760 mmHg |
| Flash Point | 102.6 ± 25.9 °C |
| Refractive Index | 1.614 |
| Packaging | 25 kg per drum |
| Storage | Store in a tightly closed container in a cool, dry, and well-ventilated area away from incompatible materials. |
Industrial Applications
This compound serves primarily as a versatile synthon in the production of active pharmaceutical ingredients (APIs). The presence of multiple orthogonal halogen handles allows chemists to perform sequential functionalization—typically leveraging the iodine site for palladium-catalyzed couplings (e.g., Suzuki, Sonogashira), while the chlorine and fluorine groups offer stability and modulate electronic properties. It is not intended for direct therapeutic use but plays an essential role in early-stage drug discovery and process-scale API manufacturing.
- Enables regioselective C–C and C–N bond formation in heterocyclic systems
- Supports modular synthesis of kinase inhibitors and CNS-targeted therapeutics
- Compatible with standard anhydrous and inert-atmosphere reaction protocols
