2-Chloro-4-Fluoro-5-Nitrobenzoic Acid
- CAS No.114776-15-7
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 2-Chloro-4-Fluoro-5-Nitrobenzoic Acid (CAS 114776-15-7), a key intermediate for antifungal pharmaceutical synthesis.
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Product Overview
2-Chloro-4-Fluoro-5-Nitrobenzoic Acid is a high-value aromatic carboxylic acid derivative widely employed as a critical synthetic intermediate in the pharmaceutical industry. With its unique substitution pattern—featuring chlorine, fluorine, and nitro groups at strategic positions on the benzoic acid scaffold—it serves as a versatile building block for complex active pharmaceutical ingredients (APIs), particularly in the development of advanced antifungal agents.
Specifications
| Molecular Formula | C₇H₃ClFNO₄ |
|---|---|
| Molecular Weight | 219.55 g/mol |
| CAS Number | 114776-15-7 |
| Appearance | White to light yellow crystalline powder |
| Assay (Purity) | ≥99.0% |
| Moisture Content | ≤0.2% |
| Melting Point | 146–150°C |
| Boiling Point | 364.2°C |
| Flash Point | 174°C |
| Refractive Index | 1.602 |
Industrial Applications
This compound is primarily utilized as a specialty intermediate in multi-step organic syntheses targeting novel therapeutic molecules. Notably, it plays an essential role in the construction of triazole-based antifungal compounds, contributing to the molecular framework required for biological activity. Its electron-withdrawing substituents enhance reactivity in nucleophilic aromatic substitution and other key transformations, making it indispensable in modern medicinal chemistry workflows.
- Enables efficient synthesis of complex pharmaceutical APIs
- High chemical stability under standard handling conditions
- Consistent batch-to-batch quality with stringent QC protocols
- Compatible with large-scale GMP manufacturing processes
Stored in a cool, dry, and well-ventilated area, 2-Chloro-4-Fluoro-5-Nitrobenzoic Acid is typically supplied in 25 kg fiber drums, with custom packaging available upon request. As a non-terminal, non-formulation ingredient, it is classified as a synthetic intermediate rather than a finished active ingredient.
