2-Hydroxyphenylboronic Acid
- CAS No.89466-08-0
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 2-Hydroxyphenylboronic acid (CAS 89466-08-0), a key boronic acid derivative widely used as a pharmaceutical intermediate in cross-coupling reactions.
Request Bulk PricingProduct Technical Details
Product Overview
2-Hydroxyphenylboronic acid is a valuable ortho-substituted arylboronic acid extensively employed in modern organic synthesis, particularly as a building block for biologically active molecules. With a molecular formula of C6H7BO3 and a molecular weight of 137.93 g/mol, this compound features a phenolic hydroxyl group adjacent to the boronic acid functionality, enabling unique chelation behavior and enhanced reactivity in Suzuki-Miyaura cross-coupling reactions. Its structural motif is frequently incorporated into drug discovery pipelines for the development of complex pharmaceutical APIs and advanced organic synthesis intermediates.
Specifications
| Molecular Formula | C6H7BO3 |
|---|---|
| Molecular Weight | 137.929 g/mol |
| Melting Point | 178–182°C |
| Boiling Point | 327.3°C at 760 mmHg |
| Density | 1.32 g/cm³ |
| Refractive Index | 1.582 |
| Flash Point | 151.7°C |
| Appearance | White powder |
| Assay (GC/HPLC) | ≥98.0% |
| Water Content (KF) | ≤0.50% |
| Hazard Classification | Non-dangerous goods |
Industrial Applications
As a specialized boronic acid derivative, 2-Hydroxyphenylboronic acid serves primarily as a high-value intermediate in the pharmaceutical and agrochemical industries. Its key applications include:
- Participation in palladium-catalyzed Suzuki couplings to construct biaryl scaffolds prevalent in drug candidates.
- Synthesis of protease inhibitors and kinase modulators through directed functionalization.
- Use in the preparation of sensors and fluorescent probes due to its metal-coordinating phenol-boronate motif.
- Employment in materials science for the development of covalent organic frameworks (COFs).
Stored in a cool, dry, and well-ventilated area with containers tightly sealed, this product maintains stability under recommended conditions. Standard packaging is 25 kg per drum, with custom configurations available upon request to meet global manufacturing needs.
