Intermediates

2-Piperazin-1-ylpyrimidine Hydrochloride

  • CAS No.78069-54-2
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity pharmaceutical intermediate used primarily in the synthesis of Buspirone Hydrochloride. Available in bulk quantities with full quality documentation.

Request Bulk Pricing

Product Technical Details

Product Overview

2-Piperazin-1-ylpyrimidine Hydrochloride is a specialized heterocyclic compound designed for advanced pharmaceutical synthesis. As a critical building block in medicinal chemistry, this substance serves as a key precursor in the manufacturing of various therapeutic agents. Our facility produces this intermediate under strict quality control protocols to ensure consistency and reliability for downstream pharmaceutical applications. We understand the vital role of high-purity intermediates in drug development and commit to delivering products that meet rigorous international standards.

Chemical Properties

This compound features a unique molecular structure combining a piperazine ring with a pyrimidine moiety, stabilized as a hydrochloride salt. The chemical stability and reactivity profile make it an ideal candidate for nucleophilic substitution reactions commonly found in complex organic synthesis. With a molecular formula of C8H13ClN4 and a molecular weight of 200.669, it exhibits specific physical characteristics that facilitate efficient processing in industrial settings. The boiling point is recorded at 328ºC at 760 mmHg, indicating robust thermal stability under standard processing conditions.

Quality Specifications

Quality assurance is the cornerstone of our manufacturing process. Every batch undergoes comprehensive testing using high-performance liquid chromatography (HPLC) to verify purity levels. We maintain an assay specification of not less than 98.0 percent to ensure optimal performance in subsequent synthesis steps. Impurity profiles are closely monitored to prevent any interference with final drug product quality. Our quality control team adheres to Good Manufacturing Practices (GMP) to provide customers with confidence in every shipment.

ParameterSpecification
AppearanceWhite powder
Assay (HPLC)≥98.0%
Molecular FormulaC8H13ClN4
Molecular Weight200.669
CAS Number78069-54-2

Industrial Applications

The primary application of this intermediate is in the synthesis of Buspirone Hydrochloride, a well-known anxiolytic agent. Beyond this specific use, the compound serves as a versatile building block for researchers developing novel neurological therapeutics. Its structural features allow for diverse chemical modifications, making it valuable in lead optimization and process chemistry. Pharmaceutical companies rely on consistent supply chains for such intermediates to maintain production schedules for essential medications.

  • High purity ensures minimal downstream purification requirements
  • Consistent batch-to-batch reproducibility for scale-up
  • Compatible with standard organic synthesis protocols
  • Supported by comprehensive technical documentation

Storage and Handling

To maintain product integrity, proper storage conditions are essential. The material should be kept in a cool, ventilated area away from direct sunlight and moisture. Standard packaging consists of 25 kg drums, though we offer flexible packaging solutions tailored to specific customer logistics requirements. Safety data sheets and certificates of analysis are provided with every order to ensure compliant handling and transportation. Our logistics team coordinates global shipping to deliver materials safely and efficiently to your production facility.