2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine

Product Overview

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine is a high-value heterocyclic building block widely employed in the synthesis of targeted kinase inhibitors and other advanced pharmaceutical actives. With its rigid fused-ring architecture and two reactive chlorine sites, this compound serves as a versatile scaffold for selective nucleophilic substitution reactions, enabling efficient construction of complex drug molecules under controlled conditions.

Specifications

Industrial Applications

This compound is primarily utilized as a critical intermediate in the multi-step synthesis of Janus kinase (JAK) inhibitors, including the active pharmaceutical ingredient (API) precursor to Tofacitinib citrate. Its dual chloro-substitution pattern allows for sequential functionalization, making it indispensable in medicinal chemistry campaigns focused on immunomodulatory and anti-inflammatory therapeutics.

• Enables regioselective derivatization for structure-activity relationship (SAR) studies
• Compatible with standard cross-coupling and displacement protocols
• Supplied in pharma-grade quality with full analytical documentation

Handling and Storage

Store in a tightly sealed container in a cool, dry environment away from direct sunlight, heat sources, and moisture. For industrial use only—handle in accordance with good manufacturing practices (GMP) and relevant chemical safety guidelines.