3,5-Bis(trifluoromethyl)bromobenzene

Product Overview

3,5-Bis(trifluoromethyl)bromobenzene is a highly specialized fluorinated aromatic compound that serves as a critical building block in modern organic synthesis. Characterized by the presence of two trifluoromethyl groups and a bromine atom on the benzene ring, this molecule offers unique electronic and steric properties that are invaluable for medicinal chemistry and agrochemical development. Our manufacturing process ensures consistent quality and high purity, making it an ideal choice for complex synthetic routes requiring robust fluorinated intermediates.

The incorporation of fluorine atoms into organic molecules is a cornerstone strategy in contemporary drug design, enhancing metabolic stability and bioavailability. This specific bromobenzene derivative facilitates various cross-coupling reactions, allowing chemists to construct sophisticated molecular architectures efficiently. We prioritize strict quality control measures throughout production to meet the demanding standards of the pharmaceutical and fine chemical industries.

Technical Specifications

Physical and Chemical Properties

Understanding the physical characteristics of this compound is essential for safe handling and effective integration into synthesis protocols. The substance exhibits a density of approximately 1.699 g/cm3, indicating a relatively heavy molecular structure due to the fluorine and bromine content. It remains liquid at room temperature with a melting point around -16 °C and a boiling point of 154 °C, facilitating easy processing under standard laboratory conditions.

• Refractive Index: 1.427
• Flash Point: >230 °F
• Stability: Stable under recommended storage conditions
• Reactivity: Compatible with standard cross-coupling reagents

Industrial Applications

This fluorinated intermediate is primarily utilized in the synthesis of advanced pharmaceutical active ingredients and agrochemical compounds. The bromine functionality allows for versatile transformations, including Suzuki, Heck, and Grignard reactions, enabling the introduction of diverse functional groups. Researchers value this material for its ability to impart lipophilicity and metabolic resistance to final drug candidates.

The electron-withdrawing nature of the trifluoromethyl groups significantly influences the reactivity of the aromatic ring, making it a superior substrate for nucleophilic substitutions compared to non-fluorinated analogs. This specific reactivity profile is crucial when designing synthesis pathways for targeted therapies where precision is paramount. Beyond pharmaceuticals, it finds application in the development of high-performance materials and specialty chemicals where fluorine content is required to modify surface properties or thermal stability.

Quality Assurance and Packaging

We adhere to rigorous quality management systems to guarantee product integrity. Each batch is accompanied by a Certificate of Analysis (COA) verifying purity and physical constants. Our facility employs state-of-the-art analytical instrumentation, including GC-MS and NMR spectroscopy, to validate the structural identity and purity levels of every production lot. We understand that impurities can drastically affect downstream reaction yields, which is why our ≥99.0% purity standard is strictly enforced.

Packaging options are designed to maintain stability during transit, available in plastic bottles for smaller quantities and plastic drums for bulk industrial requirements. Storage recommendations include keeping the container tightly closed in a cool, dry place away from incompatible substances. By choosing our supply, partners gain access to reliable quantities of this key intermediate, supported by technical expertise and competitive bulk pricing structures tailored for large-scale production needs.