3-Bromo-5-chloropicolinonitrile
- CAS No.760207-83-8
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 3-Bromo-5-chloropicolinonitrile (CAS 760207-83-8), a versatile pyridine-based building block for advanced organic synthesis in pharmaceutical and agrochemical R&D.
Request Bulk PricingProduct Technical Details
Product Overview
3-Bromo-5-chloropicolinonitrile is a high-value halogenated pyridine derivative widely employed as a key intermediate in the synthesis of complex active pharmaceutical ingredients (APIs) and specialty agrochemical compounds. With its dual functional handles—bromine for cross-coupling reactions and nitrile for further derivatization—this compound offers exceptional versatility in multi-step synthetic pathways.
Specifications
| Molecular Formula | C6H2BrClN2 |
|---|---|
| Molecular Weight | 217.451 g/mol |
| Density | 1.9 ± 0.1 g/cm³ |
| Boiling Point | 297.5 ± 40.0 °C at 760 mmHg |
| Flash Point | 133.7 ± 27.3 °C |
| Appearance | Pale yellow solid |
| Assay | ≥99.0% |
Industrial Applications
This compound serves primarily as a critical synthon in medicinal chemistry and crop protection research. Its structural features enable efficient construction of heterocyclic scaffolds through palladium-catalyzed Suzuki, Sonogashira, or Buchwald-Hartwig reactions. Common downstream applications include the development of kinase inhibitors, antimicrobial agents, and novel herbicidal molecules.
- Ideal for late-stage functionalization due to orthogonal reactivity of Br and CN groups
- Compatible with standard anhydrous and inert-atmosphere reaction conditions
- Supplied with comprehensive analytical documentation including NMR, HPLC, and MS data
Stored in a cool, well-ventilated area away from moisture and oxidizing agents, 3-Bromo-5-chloropicolinonitrile maintains stability under recommended conditions. Packaging is typically 25 kg per drum, with custom options available for large-scale industrial procurement.
