3-Ethynylaniline hydrochloride
- CAS No.207226-02-6
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High purity pharmaceutical intermediate used primarily in the synthesis of Erlotinib. Available in bulk quantities with full documentation.
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Product Overview
3-Ethynylaniline hydrochloride is a specialized organic compound serving as a critical building block in the pharmaceutical industry. Characterized by its ethynyl group attached to the aniline structure, this chemical exhibits high reactivity suitable for complex coupling reactions. Our manufacturing process ensures exceptional stability and consistency, making it an ideal choice for research and development teams focused on kinase inhibitor synthesis. As a key precursor, it plays a vital role in constructing advanced therapeutic molecules used in oncology treatments.
Technical Specifications
We adhere to strict quality control protocols to guarantee that every batch meets rigorous international standards. The following table outlines the key physical and chemical properties verified through advanced analytical methods such as HPLC and NMR spectroscopy.
| Parameter | Specification |
|---|---|
| CAS Number | 207226-02-6 |
| Molecular Formula | C8H8ClN |
| Molecular Weight | 153.61 g/mol |
| Appearance | White powder |
| Purity | ≥99.0% |
| Moisture Content | ≤0.1% |
| Total Impurities | ≤0.5% |
| Boiling Point | 275.5°C at 760 mmHg |
| Flash Point | 120.4°C |
Industrial Applications
This compound is predominantly utilized as a strategic intermediate in the multi-step synthesis of Erlotinib hydrochloride, a well-known epidermal growth factor receptor (EGFR) inhibitor. Beyond this specific application, 3-Ethynylaniline hydrochloride serves as a versatile reagent in organic synthesis laboratories. It facilitates the formation of carbon-carbon bonds through Sonogashira coupling and other palladium-catalyzed reactions. Pharmaceutical manufacturers rely on this material for developing novel anticancer agents and conducting structure-activity relationship studies. Its high purity profile minimizes downstream purification costs, enhancing overall process efficiency for large-scale production.
Quality Assurance and Safety
Our facility operates under comprehensive quality management systems to ensure product integrity. Each shipment is accompanied by a Certificate of Analysis (COA) detailing batch-specific test results. We prioritize safety throughout the supply chain. While this chemical is stable under recommended conditions, standard laboratory safety practices should be observed. Personnel should utilize appropriate personal protective equipment during handling to prevent inhalation or skin contact. We provide detailed Safety Data Sheets (SDS) upon request to support compliance with local regulatory requirements and workplace safety standards.
Packaging and Storage
To maintain optimal quality during transit and storage, the product is packaged in durable 25kg cardboard drums. Custom packaging solutions are available to meet specific logistical requirements. Storage instructions recommend keeping the container tightly closed in a cool, dry, and well-ventilated area. Protection from moisture and strong light is essential to prevent degradation. Avoid exposure to heat sources or incompatible materials. Our global logistics network ensures timely delivery while maintaining the cold chain or specific environmental controls necessary for sensitive chemical intermediates.
