3-Iodo-2-nitropyridine
- CAS No.54231-34-4
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 3-Iodo-2-nitropyridine (CAS 54231-34-4), a versatile halogenated pyridine derivative widely used as an intermediate in advanced organic synthesis.
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Product Overview
3-Iodo-2-nitropyridine is a high-value halogenated heterocyclic compound featuring both iodo and nitro functional groups on the pyridine ring. This strategic substitution pattern makes it an exceptionally useful building block in modern medicinal chemistry and agrochemical research. As a specialty intermediate, it enables selective cross-coupling reactions—such as Suzuki, Sonogashira, and Buchwald-Hartwig aminations—due to the excellent leaving-group ability of the iodine atom adjacent to the electron-withdrawing nitro group.
Specifications
| Molecular Formula | C₅H₃IN₂O₂ |
|---|---|
| Molecular Weight | 249.99 g/mol |
| Density | 2.145 g/cm³ |
| Boiling Point | 336.57°C at 760 mmHg |
| Flash Point | 157.35°C |
| Assay | ≥98.0% |
| Appearance | Yellow or light brown solid |
Industrial Applications
This compound serves primarily as a key intermediate in the synthesis of complex pharmaceutical APIs, crop protection agents, and functional materials. Its dual functionality allows for sequential derivatization: the nitro group can be reduced to an amine for further elaboration, while the C–I bond facilitates transition-metal-catalyzed transformations. Common downstream applications include the construction of kinase inhibitors, antiviral scaffolds, and novel ligands for catalysis.
- Ideal for Pd-catalyzed cross-coupling reactions
- Enables regioselective functionalization of pyridine cores
- Compatible with multi-step synthetic sequences under standard laboratory conditions
Stored in a cool, well-ventilated area away from heat and incompatible materials, 3-Iodo-2-nitropyridine is typically supplied in 25 kg drums or customized packaging to meet global regulatory and logistical requirements.
