3-Iodo-6-nitro-1-(oxan-2-yl)indazole
- CAS No.886230-74-6
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 3-iodo-6-nitro-1-(oxan-2-yl)indazole (CAS 886230-74-6), a key pharmaceutical intermediate in the synthesis of targeted kinase inhibitors.
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Product Overview
3-Iodo-6-nitro-1-(oxan-2-yl)indazole is a high-value heterocyclic building block widely employed in modern medicinal chemistry as a critical intermediate for the synthesis of advanced pharmaceutical actives. This compound features a protected indazole core with strategically positioned iodo and nitro functional groups, enabling selective cross-coupling reactions in multi-step synthetic sequences. It is particularly recognized for its role in the production of tyrosine kinase inhibitors such as Axitinib, supporting oncology drug development pipelines under strict regulatory compliance.
Specifications
| Molecular Formula | C12H12IN3O3 |
|---|---|
| Molecular Weight | 373.15 g/mol |
| Appearance | Off-white to white crystalline powder |
| Purity (HPLC) | ≥98.0% |
| Density | 2.014 g/cm³ |
| Boiling Point | 504.1°C |
| Flash Point | 258.7°C |
Industrial Applications
As a specialized intermediate, this compound is exclusively used in regulated, patent-compliant pharmaceutical manufacturing environments. Its primary application lies in the construction of complex active pharmaceutical ingredients (APIs) targeting vascular endothelial growth factor receptors (VEGFRs). The oxan (tetrahydropyran) protecting group ensures stability during synthesis while allowing for controlled deprotection in downstream steps.
- Serves as a pivotal precursor in kinase inhibitor synthesis
- Enables Pd-catalyzed coupling due to the reactive C–I bond
- Manufactured under cGMP-aligned quality systems
- Supplied with full analytical documentation including COA
Storage: Store in a cool, dry, and well-ventilated area away from incompatible materials. Packaging is typically 25 kg per drum, with custom options available upon request. Note: This product is not offered in jurisdictions where relevant patents are in force.
