4,6-Dichloro-2-(propylthio)pyrimidin-5-amine
- CAS No.145783-15-9
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High purity 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine (CAS 145783-15-9) serves as a critical intermediate for Ticagrelor synthesis, available in bulk with full COA.
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Product Overview
4,6-Dichloro-2-(propylthio)pyrimidin-5-amine is a specialized heterocyclic compound extensively utilized in the pharmaceutical industry. As a key building block, it plays an indispensable role in the synthetic route of Ticagrelor, a prominent antiplatelet medication. Our facility produces this intermediate under strict quality control protocols to ensure consistency and reliability for downstream API manufacturing.
The chemical structure features a pyrimidine core substituted with chloro, propylthio, and amino groups, providing the necessary reactivity for subsequent coupling reactions. We prioritize industrial purity standards to minimize impurity profiles that could affect the final drug substance quality.
Key Specifications
| Items of Analysis | Standard | Typical Results |
|---|---|---|
| Appearance | Yellow to yellowish brown oily matter or solid | Conforms |
| Assay | 98.0% - 102.0% | 99.75% |
| Single Impurity | ≤ 0.5% | 0.17% |
| Total Impurity | ≤ 1.0% | 0.28% |
| Water Content | ≤ 0.5% | 0.15% |
| CAS Number | 145783-15-9 | Verified |
Industrial Applications
This compound is primarily designated as a pharmaceutical intermediate. Its main application lies in the multistep synthesis of cardiovascular therapeutics. Chemical manufacturers and research institutions utilize this material for process development and commercial scale production. The high assay value ensures efficient reaction yields in subsequent synthetic steps.
- Essential precursor for Ticagrelor API synthesis
- Used in medicinal chemistry research and development
- Suitable for large-scale pharmaceutical manufacturing
- Supports custom synthesis projects for novel analogs
Quality Assurance and Safety
We adhere to rigorous quality management systems. Every batch undergoes comprehensive analysis including HPLC, KF titration, and spectral confirmation. A Certificate of Analysis (COA) is provided with each shipment to verify compliance with factory standards. Safety data sheets (SDS) are available to ensure safe handling during transport and storage.
Packaging and Storage
Standard packaging consists of 25 kg drums, though custom packaging solutions are available upon request to meet specific logistical requirements. The product should be stored in a cool, ventilated warehouse away from fire and heat sources. Storage temperatures should not exceed 37 degrees Celsius to maintain stability. Proper handling procedures must be followed to prevent exposure to moisture or incompatible substances.
