Intermediates

4-Fluoro-2-nitroaniline

  • CAS No.364-78-3
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 4-Fluoro-2-nitroaniline (CAS 364-78-3) designed for advanced organic synthesis. Reliable supply for pharmaceutical and agrochemical manufacturing processes.

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Product Technical Details

Product Overview

4-Fluoro-2-nitroaniline is a critical fluorinated aromatic intermediate widely utilized in the fine chemical and pharmaceutical industries. As a key building block, this compound offers exceptional reactivity due to the synergistic effects of the nitro and fluoro substituents on the aniline ring. Our manufacturing process ensures high consistency and purity, making it an ideal choice for complex organic synthesis pathways. We prioritize quality control at every stage, from raw material sourcing to final packaging, to meet the rigorous demands of global chemical supply chains.

This specialized intermediate is designed for researchers and industrial manufacturers who require reliable performance in multi-step synthesis reactions. The presence of the fluorine atom enhances the metabolic stability and lipophilicity of downstream products, which is particularly valuable in medicinal chemistry and agrochemical development. Our facility adheres to strict safety and environmental standards, ensuring that every batch delivered meets international specifications. We understand the importance of supply chain stability and offer scalable production capacities to support your long-term project needs.

Key Specifications

We maintain rigorous quality standards to guarantee the performance of 4-Fluoro-2-nitroaniline in your production processes. The following table outlines the typical physical and chemical properties associated with our premium grade material. Each shipment is accompanied by a Certificate of Analysis (COA) to verify compliance with these parameters. Our analytical team employs advanced chromatography and spectroscopy methods to confirm identity and purity levels.

Parameter Specification
CAS Number 364-78-3
Molecular Formula C6H5FN2O2
Molecular Weight 156.12 g/mol
Appearance Yellow to brown powder
Assay (Purity) ≥97.0%
Moisture Content ≤1.0%
Melting Point 90-94°C
Density 1.15 g/cm3
Refractive Index 1.472

Industrial Applications

The versatility of 4-Fluoro-2-nitroaniline makes it a staple in various chemical manufacturing sectors. Primarily, it serves as a precursor for the synthesis of advanced pharmaceutical APIs, where fluorinated structures are increasingly preferred for their improved bioavailability. Additionally, this compound is extensively used in the production of agrochemicals, including herbicides and pesticides, where specific substitution patterns are required for biological activity. The nitro group allows for further reduction to amines, facilitating diverse chemical transformations.

  • Pharmaceutical Intermediate: Used in the synthesis of quinolone antibiotics and other therapeutic agents requiring fluorinated scaffolds.
  • Agrochemical Synthesis: Key component in developing novel crop protection solutions with enhanced environmental profiles.
  • Dye and Pigment Industry: Employed in the creation of high-performance organic pigments with superior lightfastness.
  • Custom Organic Synthesis: Suitable for laboratory-scale research and pilot plant operations requiring precise stoichiometry.

Storage and Handling

To maintain the integrity of 4-Fluoro-2-nitroaniline, proper storage conditions are essential. The product should be kept in a cool, ventilated area away from direct sunlight and sources of ignition. Containers must be tightly sealed to prevent moisture absorption, which could affect the assay quality. We recommend using standard personal protective equipment (PPE) when handling this material, including gloves and safety goggles, to ensure workplace safety. Our packaging options include 25 kg drums, with flexibility to accommodate specific customer logistics requirements.

Partner with us for a stable supply chain of high-quality chemical intermediates. Our team provides comprehensive technical support and documentation to facilitate your regulatory compliance and production efficiency. Contact us today to discuss your bulk procurement needs and request a detailed quotation. We are committed to fostering long-term partnerships based on trust, quality, and mutual success in the global chemical market.