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5-[(4-Ethylpiperazin-1-yl)methyl]pyridin-2-amine
- CAS No.1180132-17-5
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High purity 5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-amine (CAS 1180132-17-5) serves as a critical intermediate for Abemaciclib synthesis, available in bulk quantities with full COA.
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Product Overview
5-[(4-Ethylpiperazin-1-yl)methyl]pyridin-2-amine is a specialized pharmaceutical intermediate characterized by its high chemical stability and purity. This compound plays a pivotal role in the synthetic pathway of advanced therapeutic agents, specifically serving as a key building block for the production of Abemaciclib. Our manufacturing facility ensures that every batch meets rigorous international standards, providing reliable supply chain solutions for pharmaceutical developers and contract manufacturing organizations.
As a leading global manufacturer, we understand the critical nature of intermediate quality in final drug product safety. Therefore, our production processes are optimized to minimize impurities and ensure consistent molecular integrity. This chemical is essential for researchers and industrial partners focused on oncology therapeutics and kinase inhibitor development.
Technical Specifications
The following table outlines the key physical and chemical properties verified through our quality control laboratories. Each parameter is tested to guarantee compliance with specified requirements for industrial-scale synthesis.
| Parameter | Specification |
|---|---|
| CAS Number | 1180132-17-5 |
| Molecular Formula | C12H20N4 |
| Molecular Weight | 220.314 g/mol |
| Appearance | White to off-white powder |
| Assay | ≥99.0% |
| Water Content | ≤0.5% |
| Sulfated Ash | ≤0.1% |
| Heavy Metals | ≤10ppm |
| Total Impurity | ≤0.2% |
| Boiling Point | 362.4±37.0 °C at 760 mmHg |
| Density | 1.1±0.1 g/cm3 |
Quality Assurance and Control
Quality is the cornerstone of our manufacturing philosophy. We employ advanced analytical techniques, including HPLC and NMR spectroscopy, to verify the structural identity and purity of 5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-amine. Our quality assurance team conducts multi-stage testing throughout the production cycle, from raw material intake to final packaging.
- Comprehensive Certificate of Analysis (COA) provided with every shipment.
- Strict adherence to GMP guidelines for pharmaceutical intermediates.
- Regular stability testing to ensure product integrity during storage.
- Traceability systems for batch tracking and quality audits.
Industrial Applications
This intermediate is primarily utilized in the pharmaceutical industry for the synthesis of CDK4/6 inhibitors. Its high purity profile makes it suitable for large-scale manufacturing processes where consistency is paramount. By sourcing this material from a verified supplier, partners can reduce development risks and accelerate timelines for regulatory submissions.
Packaging and Storage
To maintain optimal quality, the product is packaged in 25kg cardboard drums or according to specific customer requirements. Storage recommendations include keeping the container tightly closed in a cool, dry environment. Protection from moisture and strong light is essential to prevent degradation. We offer global logistics support to ensure timely delivery while maintaining cold chain or standard storage conditions as needed.
