Intermediates

6-Chloro-3-methyluracil

  • CAS No.4318-56-3
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 6-Chloro-3-methyluracil (CAS 4318-56-3) designed for pharmaceutical synthesis. Ideal intermediate for DPP-4 inhibitors like Trelagliptin with ≥99.0% assay.

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Product Technical Details

Product Overview

6-Chloro-3-methyluracil represents a specialized pyrimidine derivative that is extensively utilized in the modern pharmaceutical industry as a vital synthetic intermediate. This compound serves as a foundational building block for the development of advanced therapeutic agents, particularly within the realm of antidiabetic medication synthesis. Our facility produces this chemical under strict quality control protocols to ensure consistency and reliability for large-scale manufacturing processes. As a chlorinated uracil derivative, this molecule exhibits specific reactivity profiles that make it indispensable for constructing complex heterocyclic structures found in modern medicine.

The presence of the chloro group at the sixth position and the methyl group at the third position allows for selective nucleophilic substitution reactions, which are critical steps in multi-step synthesis routes. We prioritize high purity standards to minimize downstream purification challenges for our clients. Our production capabilities are designed to support both research-scale requirements and full commercial production volumes, ensuring a stable supply chain for global pharmaceutical manufacturers.

Technical Specifications

Our production batch undergoes rigorous analytical testing to confirm compliance with international pharmaceutical standards. The physical and chemical properties are tightly monitored to guarantee performance in subsequent reaction steps. We utilize advanced chromatography and spectroscopy methods to verify the identity and purity of each lot before release.

ParameterValue
Chemical Name6-Chloro-3-methyluracil
CAS Number4318-56-3
Molecular FormulaC5H5ClN2O2
Molecular Weight160.56 g/mol
AppearanceLight yellow powder
Purity≥99.0%
Density1.51 g/cm3
Boiling Point268.7 °C
Refractive Index1.58

Industrial Applications

This intermediate is primarily employed in the synthesis of dipeptidyl peptidase-4 (DPP-4) inhibitors. It acts as a crucial precursor in the manufacturing workflow for medications designed to manage blood glucose levels. Specifically, it is utilized in the production pathways for agents similar to Trelagliptin and Aglitin. Pharmaceutical manufacturers rely on the consistent quality of this raw material to ensure the efficacy and safety of the final active pharmaceutical ingredients (APIs). The chemical stability of this uracil derivative makes it suitable for various reaction conditions encountered during process development.

  • Essential building block for heterocyclic drug synthesis.
  • Used in the preparation of novel antidiabetic compounds.
  • Suitable for custom synthesis and process research.
  • Supports scale-up from laboratory to industrial production.
  • Compatible with standard organic synthesis methodologies.

Quality Assurance and Storage

We understand that stability is paramount for chemical intermediates. Our packaging solutions are designed to protect the product from moisture and light exposure during transit. Each drum is sealed to maintain integrity until it reaches your production facility. We recommend storing this material in a cool, ventilated environment away from incompatible substances. Comprehensive Certificates of Analysis (COA) are provided with every shipment to verify batch-specific quality metrics. Our commitment to excellence extends beyond mere product supply.

We offer technical support to assist with integration into your specific manufacturing processes. By choosing our 6-Chloro-3-methyluracil, you are partnering with a supplier dedicated to regulatory compliance and operational efficiency. We adhere to all relevant intellectual property regulations regarding pharmaceutical intermediates. Contact our sales team for detailed information regarding bulk pricing and lead times for global delivery. Standard packaging is 25 kg per drum, with custom options available upon request.