6-Chloro-9-(tetrahydropyran-2-yl)purine
- CAS No.7306-68-5
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity pharmaceutical intermediate essential for the synthesis of kinase inhibitors. Manufactured under strict quality controls with global supply capabilities.
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Product Overview
6-Chloro-9-(tetrahydropyran-2-yl)purine is a sophisticated heterocyclic compound widely recognized in the pharmaceutical industry as a critical building block for advanced medicinal chemistry. This purine derivative features a tetrahydropyran protecting group, which enhances stability during complex synthetic routes. Our facility specializes in the production of this high-value intermediate, ensuring consistent quality for downstream drug manufacturing processes.
As a key precursor in the development of targeted therapies, this compound plays a vital role in constructing nucleoside analogs. The chemical structure allows for selective functionalization, making it indispensable for researchers and manufacturers focused on oncology and immunology treatments. We adhere to rigorous production standards to meet the demands of global pharmaceutical supply chains.
Technical Specifications
| Parameter | Specification |
|---|---|
| CAS Number | 7306-68-5 |
| Molecular Formula | C10H11ClN4O |
| Molecular Weight | 238.67 g/mol |
| Appearance | White or off-white crystalline powder |
| Purity (HPLC) | ≥98.0% |
| Loss on Drying | ≤0.5% |
| Residue on Ignition | ≤0.1% |
| Heavy Metals | ≤20ppm |
| Boiling Point | 428.3°C |
| Density | 1.6 g/cm³ |
Industrial Applications
This compound is primarily utilized as a strategic intermediate in the synthesis of Idelalisib and related kinase inhibitors. The chloro group at the 6-position provides a reactive site for nucleophilic substitution, facilitating the introduction of various amine functionalities required for biological activity. The tetrahydropyran moiety protects the nitrogen atom during subsequent reactions, ensuring high regioselectivity and yield.
Beyond specific drug synthesis, this purine derivative serves as a valuable tool in medicinal chemistry research. It supports the development of novel therapeutic agents targeting phosphoinositide 3-kinase (PI3K) pathways. Our manufacturing process is optimized to support both pilot-scale research and large-scale commercial production, providing flexibility for clients at different stages of drug development.
Quality Assurance and Advantages
- Strict quality control protocols ensuring batch-to-batch consistency.
- Advanced analytical testing using HPLC and NMR for verification.
- Comprehensive documentation including COA and MSDS provided with every shipment.
- Scalable production capacity to meet urgent global demands.
- Compliance with international safety and environmental standards.
Storage and Handling
To maintain optimal stability, 6-Chloro-9-(tetrahydropyran-2-yl)purine should be stored in a cool, ventilated environment away from direct sunlight and moisture. The material is packaged in 25 kg drums, with custom packaging options available upon request to suit specific logistical requirements. Proper handling procedures should be followed to ensure safety during transport and storage. Our team provides full technical support to assist with integration into your synthesis workflows.
