Cyclopropylboronic Acid

Product Overview

Cyclopropylboronic Acid (CAS 411235-57-9) represents a strategically significant organoboron compound within advanced medicinal chemistry workflows. This rigorously characterized intermediate demonstrates exceptional utility in the construction of structurally complex pharmacophores, particularly valued for its cyclopropyl moiety which imparts distinctive conformational rigidity and metabolic stability to target molecules. As a critical building block in modern drug discovery pipelines, it enables the precise installation of cyclopropyl groups essential for optimizing pharmacokinetic profiles in next-generation therapeutics.

Technical Specifications

Industrial Applications

This boronic acid derivative serves as a pivotal reagent in transition-metal catalyzed cross-coupling reactions, most notably Suzuki-Miyaura protocols where it facilitates carbon-carbon bond formation with exceptional chemoselectivity. Its strained cyclopropyl architecture is instrumental in synthesizing bioactive compounds including protease inhibitors, CNS-active agents, and oncology drug candidates. The compound's compatibility with diverse functional groups enables its integration into multi-step syntheses of complex active pharmaceutical ingredients (APIs), where the cyclopropyl unit often enhances target binding affinity and reduces off-target effects.

• Enables high-yield Suzuki couplings under mild conditions
• Provides metabolic stability through constrained geometry
• Compatible with aqueous reaction media
• Facilitates rapid structural diversification in lead optimization

Quality Assurance

Manufactured under stringent ISO-certified processes, each batch undergoes comprehensive analytical validation including NMR, HPLC, and elemental analysis to ensure conformance to pharmacopeial standards. Certificate of Analysis (COA) documentation verifies purity, residual solvent levels, and heavy metal content, meeting ICH Q3C guidelines for pharmaceutical use. The compound demonstrates excellent shelf stability when stored under recommended conditions, maintaining reactivity specifications throughout its designated shelf life.

Handling & Packaging

Supplied in 25kg HDPE-lined fiber drums under inert atmosphere to prevent hydrolysis. Custom packaging configurations are available to meet specific logistical requirements. Storage mandates cool, dry environments with containers maintained under nitrogen purge to preserve boronic acid integrity. Material Safety Data Sheets (MSDS) provide comprehensive handling protocols aligned with GHS classification, confirming non-hazardous transport status under UN regulations.