D-Pyroglutamic Acid
- CAS No.4042-36-8
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity D-Pyroglutamic Acid (CAS 4042-36-8), a chiral amino acid derivative widely used as a pharmaceutical intermediate in advanced organic synthesis.
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Product Overview
D-Pyroglutamic acid is a non-proteinogenic, cyclic amino acid derivative with the molecular formula C5H7NO3 and a molecular weight of 129.11 g/mol. It serves as a valuable chiral building block in the synthesis of complex pharmaceutical active ingredients and bioactive molecules. This enantiomerically pure compound exhibits characteristic optical activity and high chemical stability, making it ideal for stereoselective synthesis in medicinal chemistry.
Specifications
| Molecular Formula | C5H7NO3 |
|---|---|
| Molecular Weight | 129.114 g/mol |
| Melting Point | 155–162°C |
| Specific Rotation | +10.8° to +12.5° |
| Assay (GC/HPLC) | ≥99.0% |
| Loss on Drying | ≤0.30% |
| Residue on Ignition | ≤0.1% |
| Chloride (Cl) | ≤0.02% |
| Iron (Fe) | ≤10 ppm |
| Arsenic (As) | ≤1 ppm |
Industrial Applications
D-Pyroglutamic acid is primarily employed as a specialty intermediate in the pharmaceutical industry. Its rigid pyrrolidone ring and carboxylic acid functionality enable its use in:
- The construction of peptidomimetics and constrained peptide analogs
- Stereospecific synthesis of neurological therapeutics and enzyme inhibitors
- Development of prodrugs and drug delivery systems leveraging lactam stability
- Chiral auxiliaries and ligands in asymmetric catalysis
Due to its well-defined stereochemistry and reactivity profile, it supports robust and scalable manufacturing processes under GMP-compliant conditions.
Handling and Storage
Store in a cool, dry, and well-ventilated area. Keep container tightly closed to prevent moisture absorption. Supplied in 25 kg fiber drums or customized packaging per client specifications. Safety data sheets and certificates of analysis (COA) are available upon request.
