(Diacetoxyiodo)benzene
- CAS No.3240-34-4
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity (Diacetoxyiodo)benzene (CAS 3240-34-4), a versatile hypervalent iodine reagent widely used as a key intermediate in oxidative transformations and pharmaceutical synthesis.
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Product Overview
(Diacetoxyiodo)benzene is a high-value hypervalent iodine(III) compound extensively employed in modern organic synthesis. With a molecular formula of C₁₀H₁₁IO₄ and a molecular weight of 322.10 g/mol, this reagent serves as a powerful, selective, and environmentally favorable oxidant compared to traditional heavy-metal alternatives. Its stability, ease of handling, and compatibility with diverse functional groups make it indispensable in fine chemical and pharmaceutical manufacturing.
Specifications
| Molecular Formula | C₁₀H₁₁IO₄ |
|---|---|
| Molecular Weight | 322.096 g/mol |
| CAS Number | 3240-34-4 |
| Appearance | White to light yellow crystal powder |
| Purity | ≥99.0% |
| Loss on Drying | ≤0.5% |
| Melting Point | 161–163 °C (lit.) |
| Density | 1.686 g/cm³ |
| Boiling Point | 456.8 °C at 760 mmHg |
| Flash Point | 230.1 °C |
Industrial Applications
As a critical synthetic intermediate, (Diacetoxyiodo)benzene enables a range of oxidative transformations under mild conditions. Notably, when combined with a catalytic amount of sodium azide in acetonitrile, it facilitates the oxidative decarboxylation of 2-aryl carboxylic acids to yield aldehydes, ketones, and nitriles—key building blocks in active pharmaceutical ingredient (API) development. It also plays a role in the synthesis pathway of complex therapeutics, including intermediates for Irinotecan (CAS 97682-44-5). Additional applications include C–H functionalization, heterocycle construction, and ligand oxidation in metal-catalyzed reactions.
- Acts as a non-toxic, metal-free oxidant alternative
- Enables high-yielding, selective transformations
- Compatible with scalable industrial processes
- Supports green chemistry initiatives by reducing heavy metal waste
Handling and Storage
Store in a tightly sealed container in a cool, dry, and well-ventilated area, away from heat sources and incompatible materials such as strong reducing agents or bases. Standard personal protective equipment (PPE) is recommended during handling. Supplied in 25 kg cardboard drums or customized packaging per client requirements.
