R-(-)-3-(Carbamoylmethyl)-5-methylhexanoic acid
- CAS No.181289-33-8
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity R-(-)-3-(Carbamoylmethyl)-5-methylhexanoic acid (CAS 181289-33-8), a key chiral intermediate in the synthesis of Pregabalin. Ideal for pharmaceutical API manufacturing with ≥99% enantiomeric purity.
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Product Overview
R-(-)-3-(Carbamoylmethyl)-5-methylhexanoic acid is a high-value chiral carboxylic acid intermediate widely employed in the asymmetric synthesis of active pharmaceutical ingredients (APIs). With CAS number 181289-33-8 and molecular formula C9H17NO3, this compound serves as a critical building block in the industrial-scale production of Pregabalin (CAS 148553-50-8), a globally recognized therapeutic agent for neuropathic pain and epilepsy.
Specifications
| Molecular Formula | C9H17NO3 |
|---|---|
| Molecular Weight | 187.24 g/mol |
| Appearance | White to off-white crystalline powder |
| Purity (HPLC) | ≥99.0% |
| Assay (HPLC) | 98.0–102.0% |
| Melting Point | 127.0–133.0°C |
| Loss on Drying | ≤0.5% |
| Residue on Ignition | ≤0.15% |
| S-Isomer | ≤1.0% |
| Heavy Metals | <20 ppm |
| Any Single Impurity | ≤0.5% |
Industrial Applications
This enantiomerically enriched intermediate is exclusively utilized in regulated pharmaceutical synthesis pathways. Its structural features—featuring a chiral center at the 3-position and a carbamoylmethyl side chain—enable precise stereochemical control during Pregabalin manufacturing. Key advantages include:
- High enantiomeric excess ensuring optimal pharmacological activity in the final API
- Excellent solubility in polar organic solvents like methanol, facilitating reaction homogeneity
- Robust thermal stability (melting point ~132°C) suitable for multi-step synthetic processes
- Low levels of genotoxic impurities and residual solvents, compliant with ICH Q3 guidelines
Manufactured under strict GMP-aligned quality systems, our product meets global regulatory standards for use in commercial drug substance production. Packaging is provided in 25 kg fiber drums with double-layer polyethylene liners, ensuring integrity during international shipping.
Storage & Handling
Store in a cool, dry, and well-closed container away from direct sunlight, moisture, and heat sources. Recommended storage temperature: 2–8°C for long-term stability. Shelf life: 24 months when stored as directed.
