(S)-4-Chloro-3-hydroxybutyronitrile

Product Overview

(S)-4-Chloro-3-hydroxybutyronitrile is a highly specialized chiral intermediate critical for the synthesis of advanced pharmaceutical compounds. As a key building block in the production of Rosuvastatin calcium, this nitrile derivative plays an indispensable role in modern cardiovascular therapeutic manufacturing. Our facility produces this compound under strict quality control standards to ensure consistent stereochemical purity and chemical integrity.

The molecular structure features a specific chiral center at the 3-position, which is vital for the biological activity of the final drug product. Maintaining the correct (S)-configuration is paramount, as the enantiomeric excess directly impacts the efficacy and safety profile of the downstream statin medication. We utilize advanced asymmetric synthesis techniques to guarantee high optical purity.

Key Specifications

Our manufacturing process is designed to meet rigorous international pharmaceutical standards. Each batch undergoes comprehensive analytical testing to verify compliance with the specified parameters. The physical appearance typically ranges from colorless to a light yellow transparent liquid, indicating high chemical stability and minimal impurity levels.

Industrial Applications

This compound serves primarily as a precursor in the multi-step synthesis of Rosuvastatin calcium, a widely prescribed HMG-CoA reductase inhibitor. The nitrile group and the chiral hydroxy functionality allow for precise chemical transformations required to construct the complex statin backbone. Pharmaceutical manufacturers rely on this intermediate for its reliability in coupling reactions and subsequent functional group modifications.

Beyond statin production, this chiral nitrile can be utilized in various organic synthesis pathways requiring a specific three-carbon chain with defined stereochemistry. Its reactivity profile makes it suitable for nucleophilic substitutions and reductions, offering versatility for research and development teams exploring new therapeutic avenues.

Quality Assurance and Safety

We implement a robust Quality Management System to ensure every drum meets the declared specifications. Certificate of Analysis (COA) documents are provided with each shipment, detailing batch-specific test results including chromatography data and optical rotation measurements. Our production facilities adhere to safety protocols regarding handling chlorinated organic compounds.

• Strict control over enantiomeric excess to prevent racemization.
• Regular equipment calibration for accurate density and boiling point measurement.
• Comprehensive stability testing under various storage conditions.
• Traceability from raw material sourcing to final packaging.

Packaging and Logistics

Standard packaging consists of 25 kg drums, designed to protect the product from moisture and light exposure during transit. Custom packaging solutions are available to accommodate specific customer requirements or large-scale industrial needs. We recommend storing the material in a cool, ventilated place away from incompatible substances to maintain shelf life.

Global shipping capabilities ensure timely delivery to pharmaceutical hubs worldwide. Our logistics team coordinates with certified carriers to handle chemical shipments in compliance with international transportation regulations. For bulk orders, we offer competitive pricing structures and dedicated technical support to assist with process integration.