(S)-(+)-4-Phenyl-2-oxazolidinone
- CAS No.99395-88-7
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity (S)-(+)-4-Phenyl-2-oxazolidinone (CAS 99395-88-7) is a critical chiral intermediate for pharmaceutical synthesis, specifically optimized for Ezetimibe production with ≥99.5% chiral assay.
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Product Overview
(S)-(+)-4-Phenyl-2-oxazolidinone is a highly specialized chiral building block extensively utilized in modern medicinal chemistry and organic synthesis. As a key oxazolidinone derivative, this compound serves as an essential stereoselective auxiliary, enabling the precise construction of complex molecular architectures required for advanced pharmaceutical applications. Our facility produces this intermediate under strict quality control protocols to ensure exceptional enantiomeric purity and chemical consistency.
The molecular structure features a robust oxazolidinone ring substituted with a phenyl group at the fourth position, providing unique reactivity profiles suitable for various transformation reactions. This specific stereochemistry is crucial for downstream synthesis pathways where chiral integrity determines the biological activity and safety profile of the final therapeutic agent.
Technical Specifications
We maintain rigorous analytical standards to guarantee product performance. Each batch undergoes comprehensive testing using high-performance liquid chromatography (HPLC) and gas chromatography (GC) to verify purity levels and enantiomeric excess. The physical properties are consistent with theoretical values, ensuring reliable handling during industrial scale-up.
| Parameter | Specification |
|---|---|
| CAS Number | 99395-88-7 |
| Molecular Formula | C9H9NO2 |
| Molecular Weight | 163.173 g/mol |
| Appearance | White to light yellow crystalline powder |
| Melting Point | 130-133 °C |
| Assay (HPLC) | ≥99.0% |
| Chiral Assay (GC) | ≥99.5% |
| Total Impurities | ≤1.0% |
| Moisture Content | ≤0.5% |
Industrial Applications
This compound is primarily recognized as a vital intermediate in the synthesis of lipid-lowering agents, specifically within the production pathway of Ezetimibe. The high enantiomeric purity ensures that the subsequent chemical steps proceed with minimal racemization, preserving the efficacy of the target molecule. Beyond this specific application, the oxazolidinone scaffold is versatile and finds utility in the development of antibiotics, antifungals, and other central nervous system therapeutics where chiral centers are pivotal.
Chemists value this material for its stability under various reaction conditions, including hydrogenation, alkylation, and hydrolysis. Its solubility profile allows for flexible processing in both laboratory-scale research and large-scale manufacturing environments. By utilizing our high-grade intermediate, pharmaceutical manufacturers can optimize their synthesis routes, reduce waste, and improve overall yield efficiency.
Quality Assurance and Storage
Quality is the cornerstone of our manufacturing process. We implement a multi-stage quality assurance system that includes raw material screening, in-process monitoring, and final product validation. Every shipment is accompanied by a Certificate of Analysis (COA) detailing batch-specific test results. Our production facilities adhere to international safety and environmental standards, ensuring sustainable and responsible chemical manufacturing.
To maintain optimal stability, the product should be stored in a cool, ventilated area away from direct sunlight and moisture. Standard packaging includes 25 kg drums, though we offer customized packaging solutions to meet specific logistical requirements. Our global supply chain ensures timely delivery to research institutions and pharmaceutical companies worldwide, supported by comprehensive technical documentation and regulatory compliance files.
