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tert-Butyl N-[(3R)-piperidin-3-yl]carbamate
- CAS No.309956-78-3
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity tert-butyl N-[(3R)-piperidin-3-yl]carbamate (CAS 309956-78-3), a key chiral building block for advanced pharmaceutical intermediates.
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Product Overview
tert-Butyl N-[(3R)-piperidin-3-yl]carbamate is a high-value chiral amine derivative widely employed as a critical intermediate in the synthesis of complex pharmaceutical active ingredients. This compound features a protected (R)-3-aminopiperidine scaffold, where the Boc (tert-butyloxycarbonyl) group ensures stability during multi-step synthetic sequences while preserving stereochemical integrity. With a purity of ≥99.0%, it meets stringent quality requirements for use in regulated drug development and manufacturing environments.
Specifications
| Molecular Formula | C₁₀H₂₀N₂O₂ |
|---|---|
| Molecular Weight | 200.28 g/mol |
| CAS Number | 309956-78-3 |
| Appearance | White powder |
| Purity | ≥99.0% |
| Melting Point | 31°C |
| Boiling Point | 304.8°C |
| Density | 1.02 g/cm³ |
| Refractive Index | 1.479 |
| Flash Point | 100°C |
| HS Code | 2933990099 |
| UN Number | UN3077 |
| Hazard Class | Class 9 |
| Packing Group | III |
Industrial Applications
This chiral Boc-protected piperidine serves as an essential building block in the production of advanced therapeutic agents, notably as a key intermediate in the synthesis of linagliptin—a dipeptidyl peptidase-4 (DPP-4) inhibitor used in type 2 diabetes management. Its well-defined stereochemistry and robust protecting group make it ideal for asymmetric synthesis routes requiring high regioselectivity and minimal racemization. The compound is compatible with standard peptide coupling protocols and deprotection conditions under mild acidic environments.
Key advantages include:
- Excellent enantiomeric purity for reliable downstream performance
- Boc protection enables orthogonal reactivity in multi-functional molecule assembly
- Scalable manufacturing under cGMP-compliant processes
- Stable under recommended storage conditions for extended shelf life
Stored in a cool, dry, and well-ventilated area, this intermediate is typically supplied in 25 kg drums or customized packaging to meet client-specific logistics and regulatory needs. Note: Supply is restricted in jurisdictions where relevant patents are in force.
