Global Manufacturers Of 4-Amino-3-Bromobenzonitrile Bulk Supply: Technical & Commercial Insights
- NINGBO INNO PHARMCHEM CO.,LTD. delivers >97% industrial purity 4-Amino-3-bromobenzonitrile via optimized synthesis routes for pharma and agrochemical applications.
- Bulk pricing is competitive with flexible MOQs (from 1 kg), full COA/SDS documentation, and REACH-compliant export capabilities.
- The compound—also known as 2-Bromo-4-cyanoaniline—is a critical building block for targeted therapeutics like Erlotinib and advanced crop protection agents.
As demand grows for high-performance aromatic intermediates in pharmaceutical and agrochemical R&D, 4-Amino-3-bromobenzonitrile (CAS 50397-74-5) has emerged as a strategically vital molecule. Its unique molecular architecture—featuring ortho-positioned bromo, amino, and cyano functional groups—enables diverse cross-coupling and cyclization reactions. When sourcing high-purity 4-Amino-3-bromobenzonitrile, buyers must prioritize suppliers with proven scale, analytical rigor, and global compliance infrastructure.
Industrial Synthesis Route and Purity Standards
The commercial production of 4-Amino-3-bromobenzonitrile typically begins with selective bromination of 4-aminobenzonitrile or diazotization/bromination of 3-bromo-4-aminobenzoic acid derivatives, followed by decarboxylation or nitrile retention strategies. At NINGBO INNO PHARMCHEM CO.,LTD., the manufacturing process is engineered to minimize di-brominated impurities and residual metals, ensuring consistent batch-to-batch performance. The final product routinely achieves ≥97% purity by HPLC, with strict control over moisture (<0.5%) and inorganic residues.
This level of industrial purity is non-negotiable for downstream applications such as Suzuki-Miyaura couplings or Buchwald-Hartwig aminations, where trace contaminants can poison catalysts or derail reaction yields. Every shipment includes a comprehensive Certificate of Analysis (COA), Safety Data Sheet (SDS), and, upon request, ISO-certified quality documentation.
Key Applications Driving Global Demand
Also referred to chemically as 2-Bromo-4-cyanoaniline, this intermediate serves three high-value sectors:
- Pharmaceutical Synthesis: Critical for constructing quinazoline-based kinase inhibitors, including oncology drugs like Erlotinib. The bromo handle allows precise C–C bond formation, while the amino group facilitates further functionalization.
- Agrochemical Development: Used in the synthesis of aryloxyphenoxypropionate herbicides (e.g., Clodinafop-propargyl analogs), where the nitrile group contributes to metabolic stability in plant systems.
- Advanced Materials & Dyes: Serves as a precursor for fluorescent probes and high-stability pigments due to its rigid, electron-deficient aromatic core.
Bulk Procurement: Pricing, Logistics, and Compliance
For procurement teams evaluating global manufacturer options, total cost extends beyond unit price. NINGBO INNO PHARMCHEM CO.,LTD. offers transparent bulk price structures with FOB Ningbo or CIF terms, MOQs starting at 1 kg for samples and scalable to multi-ton campaigns. Packaging options include 25 kg fiber drums with double-layer PE liners, compliant with IATA/IMDG for air and sea freight.
All batches are fully traceable, with documentation aligned with EU REACH, FDA DMF support, and third-party certifications (SGS, ISO 9001). Halal and Kosher certification is available for specialty markets, reinforcing supply chain integrity across regulated industries.
Comparative Supply Metrics for Bulk Buyers
| Parameter | Standard Offering | Technical Advantage |
|---|---|---|
| Purity (HPLC) | ≥97% | Low dibromo impurity (<0.3%) ensures high reaction yield |
| CAS Number | 50397-74-5 | Unambiguous customs classification (HS Code: 2926909090) |
| MOQ | 1 kg (sample); 25 kg+ (bulk) | Flexible scaling from R&D to commercial production |
| Documentation | COA, SDS, TDS, ISO certs | Full regulatory readiness for EU, US, and APAC markets |
| Lead Time | 3–7 days (in-stock); 2–4 weeks (custom synthesis) | Dedicated inventory for fast-turnaround orders |
Why Partner with NINGBO INNO PHARMCHEM CO.,LTD.?
As a premier global manufacturer of fine chemical intermediates, NINGBO INNO PHARMCHEM CO.,LTD. combines GMP-aligned production facilities with deep expertise in aromatic nitrile chemistry. Our manufacturing process for 4-Amino-3-bromobenzonitrile is continuously refined to maximize atom economy and reduce solvent waste, aligning with green chemistry principles without compromising on industrial purity.
We support clients from initial sample evaluation through long-term supply agreements, offering technical consultation on optimal handling, storage (under nitrogen, 2–8°C), and integration into complex synthesis route workflows. Whether you're developing next-generation therapeutics or sustainable crop protection agents, our commitment to quality, compliance, and responsiveness makes us a strategic partner for bulk 4-Amino-3-bromobenzonitrile procurement.