4-Amino-3-Bromobenzonitrile Bulk Price 2026: Industrial Purity, Synthesis Routes & Global Supply Outlook
- 2026 bulk pricing for 4-Amino-3-bromobenzonitrile is shaped by raw material volatility, synthesis efficiency, and demand from pharmaceutical intermediates markets.
- Industrial purity (≥98%) and reliable COA documentation are now non-negotiable for API developers—impacting both cost and procurement strategy.
- Global manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. offer scalable production with optimized synthesis routes, enabling competitive bulk pricing without compromising quality.
As the pharmaceutical and agrochemical sectors intensify R&D into novel heterocyclic scaffolds, demand for high-purity aromatic nitriles like 4-Amino-3-bromobenzonitrile continues to rise. With CAS number 50397-74-5 and molecular formula C7H5BrN2, this compound—also known as 2-Bromo-4-cyanoaniline—is a critical building block in cross-coupling reactions, particularly Suzuki and Buchwald-Hartwig aminations. For bulk buyers planning 2026 procurement, understanding the interplay between synthesis route, industrial purity, and manufacturer capabilities is essential to securing cost-effective, compliant supply.
Current Bulk Pricing Landscape for 2026
While exact 2026 bulk prices remain dynamic due to geopolitical and logistical variables, industry benchmarks suggest that high-purity (≥98%) 4-Amino-3-bromobenzonitrile will range between $850–$1,200 per kilogram for multi-kilogram orders, depending on volume, delivery terms, and certification requirements. This represents a modest 5–8% increase from 2024 levels, primarily driven by rising costs of bromination reagents and stricter environmental compliance in fine chemical manufacturing.
Notably, suppliers offering only 97% purity—as seen in some research-grade catalogs—often lack full analytical validation (e.g., HPLC, 1H NMR, residual solvent reports). In contrast, industrial users require comprehensive Certificates of Analysis (COA) confirming identity, assay, heavy metals, and residual solvents. Such quality assurance directly influences bulk price structures, as rigorous QC protocols add operational overhead but reduce downstream processing risks.
Key Factors Driving Industrial-Grade Pricing
Three primary variables determine the final bulk cost of 4-Amino-3-bromobenzonitrile in commercial transactions:
1. Synthesis Route Efficiency
The manufacturing process significantly impacts yield, impurity profile, and scalability. The most common industrial synthesis involves selective bromination of 4-aminobenzonitrile under controlled conditions, followed by purification via recrystallization or chromatography. Alternative routes starting from 3-bromoaniline may introduce regioisomeric impurities (e.g., 4-amino-2-bromobenzonitrile), requiring additional separation steps that inflate costs. Leading global manufacturers optimize their synthesis route to maximize atom economy and minimize halogenated waste—key factors in sustainable, cost-competitive production.
2. Industrial Purity & Analytical Documentation
Pharmaceutical intermediates demand ≥98% purity with full traceability. Buyers should verify that the supplier provides batch-specific COA data, including:
- HPLC assay (typically ≥98.0%)
- Melting point (106–110°C)
- Residual solvents (per ICH Q3C)
- Heavy metals (≤10 ppm)
Suppliers cutting corners on analytical rigor may offer lower initial quotes but expose buyers to costly reprocessing or regulatory delays.
3. Order Volume and Logistics
Economies of scale apply strongly in fine chemical procurement. Minimum order values often start at $1,000 USD, but true bulk pricing (sub-$900/kg) typically requires 10+ kg commitments. Additionally, Incoterms (e.g., FOB Ningbo vs. DDP Rotterdam) and packaging (drums vs. multi-layer bags) affect landed costs. Reliable global manufacturers maintain ISO-certified facilities and export compliance systems to streamline international shipments.
Why Source from NINGBO INNO PHARMCHEM CO.,LTD.?
As a premier global manufacturer of high-value aromatic intermediates, NINGBO INNO PHARMCHEM CO.,LTD. combines advanced process chemistry with GMP-aligned quality systems to deliver 4-Amino-3-bromobenzonitrile at industrial scale. Their proprietary synthesis route ensures consistent ≥98.5% purity, low genotoxic impurity risk, and rapid batch turnaround—critical for time-sensitive API campaigns.
Unlike catalog vendors who repackage research-grade material without full COA support, NINGBO INNO PHARMCHEM CO.,LTD. provides end-to-end transparency: from raw material sourcing to final release testing. This vertical integration enables stable 2026 bulk pricing even amid market fluctuations.
Bulk Procurement Comparison: Key Specifications
| Parameter | Research-Grade (Typical) | Industrial-Grade (NINGBO INNO PHARMCHEM) |
|---|---|---|
| CAS Number | 50397-74-5 | 50397-74-5 |
| Purity | 97% (no full COA) | ≥98.5% (HPLC, NMR, GC verified) |
| Synthesis Route | Unspecified / legacy method | Optimized bromination with impurity control |
| COA Availability | Limited or none | Full analytical dossier per batch |
| MOQ | 1–5 g (high $/g) | 1 kg (scalable to metric tons) |
| 2026 Est. Bulk Price (10+ kg) | N/A (not offered) | $850–$1,050/kg (FOB China) |
How to Request a Custom Quote for 2026 Delivery
For bulk buyers evaluating 2026 supply contracts, direct engagement with qualified manufacturers is essential. When requesting a quote, specify:
- Required quantity (kg or MT)
- Target purity and analytical standards (e.g., EP, USP, customer-specific)
- Preferred delivery timeline and Incoterms
- Intended application (e.g., pharmaceutical intermediate, agrochemical synthesis)
Reputable suppliers like NINGBO INNO PHARMCHEM CO.,LTD. respond with detailed quotations including COA templates, safety data sheets (SDS), and scalability assessments—ensuring alignment with your development or production schedule.
In summary, the 2026 bulk price for 4-Amino-3-bromobenzonitrile reflects more than just chemical cost—it embodies the value of a robust, auditable supply chain. By prioritizing industrial purity, validated synthesis routes, and partnership with a certified global manufacturer, buyers secure both economic efficiency and regulatory confidence.