Industrial Purity Specifications and COA for 4-Amino-3-Bromobenzonitrile
- High-purity 4-Amino-3-bromobenzonitrile meets ≥98% assay standards with full Certificate of Analysis (CoA) documentation.
- Industrial-grade material is optimized for scalable synthesis routes in API development and transition metal catalysis.
- NINGBO INNO PHARMCHEM CO.,LTD. supplies bulk quantities with cGMP-aligned manufacturing and global logistics support.
For B2B buyers in the pharmaceutical, agrochemical, and advanced materials sectors, the quality and consistency of intermediates like 4-Amino-3-bromobenzonitrile directly impact downstream reaction yields, regulatory compliance, and cost efficiency. As a key building block in modern organic synthesis, this compound—also known by its alternative nomenclature 2-Bromo-4-cyanoaniline—demands rigorous quality control, especially when deployed in commercial-scale processes.
Certificate of Analysis (CoA): The Quality Benchmark
A comprehensive Certificate of Analysis (CoA) is non-negotiable for industrial procurement of 4-Amino-3-bromobenzonitrile. The CoA validates that each batch conforms to predefined purity thresholds and safety parameters. At NINGBO INNO PHARMCHEM CO.,LTD., every lot undergoes multi-tier analytical verification, including HPLC, GC, ICP-MS, and Karl Fischer titration, ensuring alignment with both client specifications and international pharmacopeial guidelines.
Critical quality metrics typically documented in the CoA include:
- Assay purity ≥98% (HPLC area normalization)
- Residual solvents below ICH Q3C limits (e.g., toluene, DMF, methanol)
- Heavy metals (Pb, Cd, Hg, As) ≤10 ppm by ICP-MS
- Water content ≤0.5% (Karl Fischer)
- Appearance and melting point consistent with reference standards
Industrial Purity vs. Lab-Grade: Why It Matters
While research-grade 4-Amino-3-bromobenzonitrile may suffice for milligram-scale screening, industrial applications demand higher consistency and lower impurity profiles. Impurities such as unreacted bromo precursors, isomeric byproducts, or residual catalysts can poison sensitive catalytic systems or introduce genotoxic risks in active pharmaceutical ingredients (APIs).
NINGBO INNO PHARMCHEM CO.,LTD. specializes in industrial purity grades tailored for process chemistry, with optimized synthesis routes that minimize side reactions and maximize isolated yield. Our proprietary manufacturing process ensures batch-to-batch reproducibility—critical for clients scaling from kilogram to metric-ton volumes.
Key Applications Driving Demand for High-Purity Material
The versatility of 4-Amino-3-bromobenzonitrile stems from its dual functional handles: the electron-rich aromatic amine and the electrophilic bromide adjacent to a cyano group. This enables diverse transformations, including:
- Pharmaceutical synthesis as key building blocks for API development (e.g., kinase inhibitors, CNS agents)
- Ligand design for transition metal catalysis, particularly in Suzuki-Miyaura and Buchwald-Hartwig couplings
- Intermediate in specialty polymers, dyes, and photoresists requiring precise molecular architecture
For these applications, even minor deviations in purity can cascade into failed reactions or costly purification steps. Hence, sourcing from a global manufacturer with robust quality infrastructure is essential.
Bulk Procurement and Commercial Advantages
When evaluating suppliers, B2B buyers should prioritize partners offering transparent CoA data, scalable production capacity, and competitive bulk price structures. NINGBO INNO PHARMCHEM CO.,LTD. provides flexible order sizes—from 1 kg to multi-ton campaigns—with volume-based pricing and long-term supply agreements.
Our facility adheres to ISO 9001 and cGMP-aligned practices, ensuring traceability from raw materials to final packaged product. Every shipment includes a full dossier: CoA, Safety Data Sheet (SDS), and, upon request, spectral data (¹H NMR, ¹³C NMR, LC-MS).
Technical Specifications Overview
| Parameter | Specification | Test Method |
|---|---|---|
| CAS Number | 50397-74-5 | — |
| Molecular Formula | C₇H₅BrN₂ | — |
| Molecular Weight | 197.03 g/mol | — |
| Assay (HPLC) | ≥98.0% | USP <621> |
| Residual Solvents | Complies with ICH Q3C | GC-FID |
| Heavy Metals | ≤10 ppm total | ICP-MS |
| Water Content | ≤0.5% | Karl Fischer |
| Appearance | Off-white to light brown crystalline powder | Visual |
Conclusion: Quality You Can Scale With
In high-stakes chemical manufacturing, the reliability of your intermediates defines your operational success. 4-Amino-3-bromobenzonitrile is no exception—its role in complex syntheses demands uncompromising purity and documentation. As a premier global manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. delivers industrial purity material backed by rigorous CoA validation, scalable manufacturing process controls, and responsive technical support.
Whether you're optimizing a new synthesis route or securing long-term supply for commercial production, partnering with a supplier that understands both chemistry and commerce ensures performance, compliance, and value.