4-Amino-3-bromobenzonitrile
- CAS No.50397-74-5
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 4-Amino-3-bromobenzonitrile (CAS 50397-74-5), a versatile brominated aromatic intermediate for advanced organic synthesis in pharmaceutical and agrochemical R&D.
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Product Overview
4-Amino-3-bromobenzonitrile is a high-value brominated aromatic building block widely employed in the synthesis of complex organic molecules. With its dual functional groups—an amino group and a nitrile moiety—positioned ortho to a bromine atom, this compound offers exceptional regioselectivity for cross-coupling reactions, nucleophilic substitutions, and heterocycle formations. It serves as a critical intermediate in the development of active pharmaceutical ingredients (APIs), crop protection agents, and specialty materials.
Specifications
| Molecular Formula | C₇H₅BrN₂ |
|---|---|
| Molecular Weight | 197.032 g/mol |
| CAS Number | 50397-74-5 |
| Appearance | Light yellow to brown powder |
| Assay | ≥98.0% |
| Melting Point | 106–110 °C (lit.) |
| Density | 1.7 ± 0.1 g/cm³ |
| Boiling Point | 300.3 ± 27.0 °C at 760 mmHg |
| Flash Point | 135.4 ± 23.7 °C |
| Vapour Pressure | 0.0 ± 0.6 mmHg at 25 °C |
| Refractive Index | 1.652 |
Industrial Applications
This brominated benzonitrile derivative is primarily utilized as a synthetic intermediate in multi-step organic transformations. Key applications include:
- Serving as a precursor in palladium-catalyzed Suzuki, Sonogashira, and Buchwald-Hartwig coupling reactions.
- Enabling the construction of nitrogen-containing heterocycles such as quinazolines and benzimidazoles.
- Facilitating the development of novel compounds in medicinal chemistry programs targeting kinase inhibitors and other therapeutic modalities.
- Supporting agrochemical innovation through the synthesis of structurally diverse bioactive molecules.
Supplied in 25 kg drums with custom packaging available upon request, 4-Amino-3-bromobenzonitrile should be stored in a cool, dry, and well-ventilated area away from incompatible substances to maintain stability and performance.
